Dose-Response Relationship, Drug
Research News and Information

Sunday, November 08, 2009

The effects of ultrasound guidance and neurostimulation on the minimum effective anesthetic volume of mepivacaine 1.5% required to block the sciatic nerve using the subgluteal approach.

30 Oct 2009 BACKGROUND: We tested the hypothesis that ultrasound (US) guidance may reduce the minimum effective anesthetic volume (MEAV(50)) of 1.5% mepivacaine required to block the sciatic nerve with a subgluteal approach compared with neurostimulation (NS). ... Read more...

A randomized comparison of low doses of hyperbaric bupivacaine in combined spinal-epidural anesthesia for cesarean delivery.

30 Oct 2009 BACKGROUND: The aim of our study was to investigate the block characteristics of intrathecal hyperbaric bupivacaine 7, 8, or 9 mg administered during combined spinal-epidural anesthesia for cesarean delivery and to elucidate the dose that produces ... Read more...

Volatile anesthetics attenuate oxidative stress-reduced activity of glutamate transporter type 3.

30 Oct 2009 BACKGROUND: Volatile anesthetics enhance the activity of glutamate transporter Type 3 (also called excitatory amino acid transporter Type 3, EAAT3), the major neuronal EAAT. In addition to glutamate, EAAT3 can also uptake L-cysteine, the ... Read more...

Latest indexed articles for 'Dose-Response Relationship, Drug'

These are the very latest articles for this heading:

• The effects of ultrasound guidance and neurostimulation on the minimum effective anesthetic volume of mepivacaine 1.5% required to block the sciatic nerve using the subgluteal approach. 30 Oct 2009
• A randomized comparison of low doses of hyperbaric bupivacaine in combined spinal-epidural anesthesia for cesarean delivery. 30 Oct 2009
• Volatile anesthetics attenuate oxidative stress-reduced activity of glutamate transporter type 3. 30 Oct 2009
• Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation. 30 Oct 2009
• The effects of sevoflurane and propofol on glucose metabolism under aerobic conditions in fed rats. 30 Oct 2009
• Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion. 30 Oct 2009
• Neuraxial anesthesia for cesarean delivery: what criteria define the "optimal" technique? 30 Oct 2009
• Challenges in developing evidence-based drug dosing guidelines for adults and children receiving renal replacement therapy. 30 Oct 2009
• Continuing the use of the Cockcroft-Gault equation for drug dosing in patients with impaired renal function. 30 Oct 2009
• Use of the MDRD study equation to estimate kidney function for drug dosing. 30 Oct 2009
• Nephropharmacology: drugs and the kidney. 30 Oct 2009
• Effect of ibuprofen on osteoblast differentiation of porcine bone marrow-derived progenitor cells. 30 Oct 2009
• Enhanced MDR1 expression and chemoresistance of cancer stem cells derived from glioblastoma. 30 Oct 2009
• The impacts of ERCC1 gene exon VIII alternative splicing on cisplatin-resistance in ovarian cancer cells. 30 Oct 2009
• Diclofenac sodium inhibits NFkappaB transcription in osteoclasts. 30 Oct 2009
• Radiosensitization effect of STI-571 on pancreatic cancer cells in vitro. 30 Oct 2009
• Preliminary evaluation of the effect of dutasteride on PCA3 in post-DRE urine sediments: a randomized, open-label, parallel-group pilot study. 30 Oct 2009
• Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. 19 Oct 2009
• Kv7/KCNQ channels control action potential phasing of pyramidal neurons during hippocampal gamma oscillations in vitro. 19 Oct 2009
• Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord. 19 Oct 2009

See a longer list of these articles.

Technical information about 'Dose-Response Relationship, Drug'

Definition: The relationship between the dose of an administered drug and the response of the organism to the drug.

Descriptor UI: D004305

Alternative terms: Dose-Response Relationship, Drug; Dose-Response Relationships, Drug; Drug Dose-Response Relationship; Drug Dose-Response Relationships; Relationship, Drug Dose-Response; Relationships, Drug Dose-Response; Dose Response Relationship, Drug;

Tree Number: G07.690.220;

History Note: 73

Technical Notes: no qualif; IM if general, NIM when coord for specific drug; DF: DOSE RESPONSE RELAT DRUG