Down-Regulation
Research News and Information

Sunday, November 22, 2009

Human cytomegalovirus productively infects adrenocortical cells and induces an early cortisol response.

29 Nov 2009 Following our recent findings on the presence of human cytomegalovirus (HCMV) in the normal human adrenal cortex and in adrenocortical tumors, especially in cortisol-secreting tumors, aim of the present study was to investigate the direct effects of ... Read more...

Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1.

29 Nov 2009 p21-Activated kinase 1 (Pak1), a serine/threonine kinase, has been implicated in cytoskeletal remodelling, cell motility, apoptosis and transformation. However, the role of Pak1 in gastric cancer remains unclear. In this study, we detected Pak1 ... Read more...

Aberrant underexpression of CD81 in precursor B-cell acute lymphoblastic leukemia: utility in detection of minimal residual disease by flow cytometry.

30 Oct 2009 We studied CD81 expression by flow cytometry (FC) on benign precursor B cells (hematogones) and leukemic blasts in precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) and established its usefulness in minimal residual disease (MRD) assays. ... Read more...

Latest indexed articles for 'Down-Regulation'

These are the very latest articles for this heading:

• Human cytomegalovirus productively infects adrenocortical cells and induces an early cortisol response. 29 Nov 2009
• Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1. 29 Nov 2009
• Aberrant underexpression of CD81 in precursor B-cell acute lymphoblastic leukemia: utility in detection of minimal residual disease by flow cytometry. 30 Oct 2009
• Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons. 30 Oct 2009
• Cytokines decrease expression of interleukin-6 signal transducer and leptin receptor in central nervous system glia. 30 Oct 2009
• Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation. 30 Oct 2009
• Upregulated p27kip1 can downregulate survivin expression and inhibit telomerase activity in gastric carcinoma cells. 30 Oct 2009
• Diclofenac sodium inhibits NFkappaB transcription in osteoclasts. 30 Oct 2009
• CCR5 down-regulates osteoclast function in orthodontic tooth movement. 30 Oct 2009
• CXCL14 inhibits trophoblast outgrowth via a paracrine/autocrine manner during early pregnancy in mice. 30 Oct 2009
• E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells. 30 Oct 2009
• Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. 17 Oct 2009
• TCR down-regulation controls T cell homeostasis. 13 Oct 2009
• Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling. 10 Oct 2009
• Colony-stimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-{kappa}B ligand (RANKL) expression by osteoblasts. 7 Oct 2009
• KLF family members regulate intrinsic axon regeneration ability. 7 Oct 2009
• Novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer. 6 Oct 2009
• Thrombomodulin in atypical hemolytic-uremic syndrome. 6 Oct 2009
• An integrated systems analysis implicates EGR1 downregulation in simian immunodeficiency virus encephalitis-induced neural dysfunction. 5 Oct 2009
• Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study. 3 Oct 2009

See a longer list of these articles.

Technical information about 'Down-Regulation'

Definition: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Descriptor UI: D015536

Alternative terms: Down-Regulation; Down Regulation; Downregulation; Down-Regulation (Physiology); Receptor Down-Regulation; Down-Regulation, Receptor;

Related Mesh Headings: Up-Regulation; Feedback, Biochemical;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G02.111.087.225; G02.149.115.225; G05.355.315.200; G07.690.812.230; G07.700.360.487.500; G07.700.680.230;

History Note: 2002 (1990)

Technical Notes: DF: DOWN REG