Drug Antagonism
Research News and Information

Sunday, November 22, 2009

Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL.

9 Aug 2009 HER2-directed therapies, such as trastuzumab and lapatinib, are important treatments for breast cancer. However, some tumors do not respond or develop resistance to these agents. We isolated and characterized multiple lapatinib-resistant, ... Read more...

An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant.

14 Jul 2009 The human serotonin transporter (hSERT) has primary and allosteric binding sites for escitalopram and R-citalopram. Previous studies have established that the interaction of these two compounds at a low affinity allosteric binding site of hSERT can ... Read more...

Serum or bile affects the in vitro azole susceptibilities of Candida spp.

29 Jun 2009 Drug susceptibility tests were performed with a series of Candida spp. in media supplemented with serum or bile. The azole susceptibilities of several medically important Candida spp., including C. albicans but not C. parapsilosis, were ... Read more...

Latest indexed articles for 'Drug Antagonism'

These are the very latest articles for this heading:

• Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL. 9 Aug 2009
• An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant. 14 Jul 2009
• Case records of the Massachusetts General Hospital. Case 22-2009. A 59-year-old man with skin and pulmonary lesions after chemotherapy for leukemia [corrected]. 14 Jul 2009
• Serum or bile affects the in vitro azole susceptibilities of Candida spp. 29 Jun 2009
• The effect of olanzapine pretreatment on acute cocaine toxicity in mice. 29 Jun 2009
• Preventive effect of Tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male Wistar rats. 7 Jun 2009
• Induction of heme oxygenase-1 with hemin attenuates hippocampal injury in rats after acute carbon monoxide poisoning. 7 Jun 2009
• Imipramine counteracts corticosterone-induced alterations in the effects of the activation of 5-HT(7) receptors in rat hippocampus. 30 May 2009
• Effect of pyridostigmine (Mestinon) on human platelet aggregation. 30 May 2009
• Expression of transforming growth factor-beta and determination of apoptotic index in histopathological sections for assessment of the effects of Apigenin (4', 5', 7'- Trihydroxyflavone) on Cyclosporine A induced renal damage. 30 May 2009
• Drug interactions and the evolution of antibiotic resistance. 30 May 2009
• Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone. 29 Apr 2009
• Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1. 22 Apr 2009
• Melatonin prevents the development of hyperplastic urothelium induced by repeated doses of cyclophosphamide. 19 Apr 2009
• Mercury-selenium compounds and their toxicological significance: toward a molecular understanding of the mercury-selenium antagonism. 15 Apr 2009
• Ligand binding and micro-switches in 7TM receptor structures. 14 Apr 2009
• Developmental toxicity of ethanol in chick heart in ovo and in micromass culture can be prevented by addition of vitamin C and folic acid. 8 Apr 2009
• Protection of bleomycin-induced fibrosis and inflammation by taurine. 7 Apr 2009
• Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice. 30 Mar 2009
• Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA. 24 Mar 2009

See a longer list of these articles.

Technical information about 'Drug Antagonism'

Definition: Phenomena and pharmaceutics of compounds that inhibit the function of agonists (AGONISM) and inverse agonists (INVERSE AGONISM) for a specific receptor. On their own, antagonists produce no effect by themselves to a receptor, and are said to have neither intrinsic activity nor efficacy.

Descriptor UI: D004336

Alternative terms: Drug Antagonism; Antagonism, Drug; Antagonisms, Drug; Drug Antagonisms;

Related Mesh Headings: Narcotic Antagonists;

Tree Number: G07.690.812.240.310; G07.700.680.240.310;

History Note: 68(66)

Technical Notes: general only; prefer specific drug with /antag; DF: DRUG ANTAG