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Drug Evaluation, Preclinical - Statistics & numerical data
Research News and Information
Definition of 'Drug Evaluation, Preclinical'Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. Common names: Drug Evaluation, Preclinical; Drug Evaluations, Preclinical; Drug Screening; Drug Screenings; Screening, Drug; Screenings, Drug; Evaluation Studies, Drug, Pre-Clinical; Preclinical Drug Evaluations; Evaluation, Preclinical Drug; Evaluations, Preclinical Drug; Preclinical Drug Evaluation |
Sunday, November 22, 2009
Graph wavelet alignment kernels for drug virtual screening.
30 May 2009 
In this paper, we introduce a novel statistical modeling technique for target property prediction, with applications to virtual screening and drug design. In our method, we use graphs to model chemical structures and apply a wavelet analysis of ... Read more...
WebFlow: a software package for high-throughput analysis of flow cytometry data.
30 Jan 2009 Flow cytometry has emerged as a powerful tool for quantitative, single-cell analysis of both surface markers and intracellular antigens, including phosphoproteins and kinase signaling cascades, with the flexibility to process hundreds of samples in ... Read more...
Structure-based drug design: from nucleic acid to membrane protein targets.
29 Jan 2009 The in silico methods for drug discovery are becoming increasingly powerful and useful. That, in combination with increasing computer processor power, in our case using a novel distributed computing grid, has enabled us to greatly enhance our ... Read more...
Latest indexed articles for 'Drug Evaluation, Preclinical - Statistics & numerical data'
These are the very latest articles for this heading:
- Graph wavelet alignment kernels for drug virtual screening. 30 May 2009
- WebFlow: a software package for high-throughput analysis of flow cytometry data. 30 Jan 2009
- Structure-based drug design: from nucleic acid to membrane protein targets. 29 Jan 2009
- Review of statistical methodologies used to compare (bio)assays. 27 Jan 2009
- A decision algorithm for translating preclinical trial results to enhance recovery after stroke. 30 Dec 2008
- Investigating association between behavior, corticosterone, heart rate, and blood pressure in rats using surrogate marker evaluation methodology. 30 Dec 2008
- Lead finder: an approach to improve accuracy of protein-ligand docking, binding energy estimation, and virtual screening. 29 Nov 2008
- Kinase-targeted library design through the application of the PharmPrint methodology. 29 Nov 2008
- Clustering and classifying diverse HIV entry inhibitors using a novel consensus shape-based virtual screening approach: further evidence for multiple binding sites within the CCR5 extracellular pocket. 30 Oct 2008
- Practical outcomes of applying ensemble machine learning classifiers to High-Throughput Screening (HTS) data analysis and screening. 30 Oct 2008
- Targets looking for drugs: a multistep computational protocol for the development of structure-based pharmacophores and their applications for hit discovery.
30 Oct 2008 - Identification and selection of "privileged fragments" suitable for primary screening. 30 Oct 2008
- FieldScreen: virtual screening using molecular fields. Application to the DUD data set. 30 Oct 2008
- Virtual screening for R-groups, including predicted pIC50 contributions, within large structural databases, using Topomer CoMFA. 30 Oct 2008
- Protein-ligand docking against non-native protein conformers. 30 Oct 2008
- High throughput ADME screening: practical considerations, impact on the portfolio and enabler of in silico ADME models. 30 Oct 2008
- Design of a grid service-based platform for in silico protein-ligand screenings. Sep 2008
- The identification of benefit in medical intervention: an overview and suggestions for process. 30 Aug 2008
- Regression analyses of southern African ethnomedicinal plants: informing the targeted selection of bioprospecting and pharmacological screening subjects. 5 Aug 2008
- Assessing non-inferiority of a new treatment in a three-arm trial in the presence of heteroscedasticity. 18 Feb 2008
See a longer list of these articles.
Technical information about 'Drug Evaluation, Preclinical'
Definition: Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Descriptor UI: D004353
Alternative terms: Drug Evaluation, Preclinical; Drug Evaluations, Preclinical; Drug Screening; Drug Screenings; Screening, Drug; Screenings, Drug; Evaluation Studies, Drug, Pre-Clinical; Preclinical Drug Evaluations; Evaluation, Preclinical Drug; Evaluations, Preclinical Drug; Preclinical Drug Evaluation; Drug Evaluation Studies, Preclinical; Evaluation Studies, Drug, Preclinical; Medicinal Plants Testing, Preclinical;
Related Mesh Headings: Toxicity Tests;
Allowable Qualifiers: adverse effects; classification; economics; history; instrumentation; methods; mortality; nursing; psychology; standards; trends; utilization; veterinary; statistics & numerical data; contraindications; ethics;
Tree Number: E05.295.750; E05.337.550;
History Note: 74; was in Cat E & G 1974-79
Technical Notes: IM when general; NIM with specific drug; used for studies in experimental animals or in vitro;` do not confuse entry term DRUG SCREENING for screening for substance abuse (= SUBSTANCE ABUSE DETECTION)