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Drug Evaluation, Preclinical
Research News and Information
Definition of 'Drug Evaluation, Preclinical'Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. Common names: Drug Evaluation, Preclinical; Drug Evaluations, Preclinical; Drug Screening; Drug Screenings; Screening, Drug; Screenings, Drug; Evaluation Studies, Drug, Pre-Clinical; Preclinical Drug Evaluations; Evaluation, Preclinical Drug; Evaluations, Preclinical Drug; Preclinical Drug Evaluation |
Sunday, November 22, 2009
Targeting protein kinases in central nervous system disorders.
30 Oct 2009 
Protein kinases are a growing drug target class in disorders in peripheral tissues, but the development of kinase-targeted therapies for central nervous system (CNS) diseases remains a challenge, largely owing to issues associated specifically with ... Read more...
6 Oct 2009 Preclinical and clinical research findings have revealed that the hormone progesterone, when acutely administered, can dramatically reduce cerebral edema, inflammation, tissue necrosis, and programmed cell death following traumatic brain injury ... Read more...
Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
6 Oct 2009 Molecular disruption of the lipid carrier AFABP/aP2 in mice results in improved insulin sensitivity and protection from atherosclerosis. Because small molecule inhibitors may be efficacious in defining the mechanism(s) of AFABP/aP2 action, a ... Read more...
Latest indexed articles for 'Drug Evaluation, Preclinical'
These are the very latest articles for this heading:
- Targeting protein kinases in central nervous system disorders. 30 Oct 2009
- Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury. 6 Oct 2009
- Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins. 6 Oct 2009
- Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. 6 Oct 2009
- Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. 6 Oct 2009
- Discovery of novel types of inhibitors of S-adenosylmethionine synthesis by virtual screening. 6 Oct 2009
- Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation. 29 Sep 2009
- Quinaprilat: a review of its pharmacokinetics, pharmacodynamics, toxicological data and clinical application. 29 Sep 2009
- Neridronic acid for the treatment of bone metabolic diseases. 29 Sep 2009
- Ferumoxytol for treatment of iron deficiency anemia in patients with chronic kidney disease. 29 Sep 2009
- Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector. 29 Sep 2009
- Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization. 29 Sep 2009
- Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening. 22 Sep 2009
- Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands. 22 Sep 2009
- Automated docking screens: a feasibility study. 22 Sep 2009
- On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences. 22 Sep 2009
- Structural artifacts in protein-ligand X-ray structures: implications for the development of docking scoring functions. 22 Sep 2009
- Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat. 12 Sep 2009
- Chemical genetic screening in the zebrafish embryo. 8 Sep 2009
- Identification of specific small molecule ligands for stem loop 3 ribonucleic acid of the packaging signal Psi of human immunodeficiency virus-1. 8 Sep 2009
See a longer list of these articles.
Technical information about 'Drug Evaluation, Preclinical'
Definition: Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Descriptor UI: D004353
Alternative terms: Drug Evaluation, Preclinical; Drug Evaluations, Preclinical; Drug Screening; Drug Screenings; Screening, Drug; Screenings, Drug; Evaluation Studies, Drug, Pre-Clinical; Preclinical Drug Evaluations; Evaluation, Preclinical Drug; Evaluations, Preclinical Drug; Preclinical Drug Evaluation; Drug Evaluation Studies, Preclinical; Evaluation Studies, Drug, Preclinical; Medicinal Plants Testing, Preclinical;
Related Mesh Headings: Toxicity Tests;
Allowable Qualifiers: adverse effects; classification; economics; history; instrumentation; methods; mortality; nursing; psychology; standards; trends; utilization; veterinary; statistics & numerical data; contraindications; ethics;
Tree Number: E05.295.750; E05.337.550;
History Note: 74; was in Cat E & G 1974-79
Technical Notes: IM when general; NIM with specific drug; used for studies in experimental animals or in vitro;` do not confuse entry term DRUG SCREENING for screening for substance abuse (= SUBSTANCE ABUSE DETECTION)