Drug Hypersensitivity - Genetics
Research News and Information

Sunday, November 22, 2009

Genetic effect of CysLTR2 polymorphisms on its mRNA synthesis and stabilization.

18 Oct 2009 BACKGROUND: We previously demonstrated that single nucleotide polymorphism (SNP) and haplotypes were associated with aspirin hypersensitivity in asthmatics. We investigated the genetic effects of the SNPs and haplotypes on the expression of the ... Read more...

Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma.

17 Sep 2009 BACKGROUND: NLR family, pyrin domain containing 3 (NLRP3), controls the activity of inflammatory caspase-1 by forming inflammasomes, which leads to cleavage of the procytokines IL-1beta and IL-18. Recent studies have shown associations of human ... Read more...

Improving drug safety by locating genetic markers for hypersensitivity reactions.

30 May 2009 Individuals vary in their response to a medication with regard to efficacy and adverse effects. The human leukocyte antigen (HLA) region of DNA offers the key to predicting drug hypersensitivity reactions. Single nucleotide polymorphisms for ... Read more...

Latest indexed articles for 'Drug Hypersensitivity - Genetics'

These are the very latest articles for this heading:

• Genetic effect of CysLTR2 polymorphisms on its mRNA synthesis and stabilization. 18 Oct 2009
• Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. 17 Sep 2009
• Foreword. Drug allergy and primum non-nocere. 30 Jul 2009
• Lack of association of ALOX12 and ALOX15 polymorphisms with aspirin-exacerbated respiratory disease in Korean patients. 29 Jun 2009
• The convenience of flow cytometry for HLA-B*5701 screening to prevent abacavir hypersensitivity reactions. 29 Jun 2009
• Improving drug safety by locating genetic markers for hypersensitivity reactions. 30 May 2009
• Polymorphisms and haplotype analysis of IL-4Ralpha Q576R and I75V in patients with penicillin allergy. 5 May 2009
• FDA, researchers focus on genetics of drug hypersensitivity. 29 Apr 2009
• Genetics of antiepileptic drug resistance. 30 Mar 2009
• Genetic basis for idiosyncratic reactions to antiepileptic drugs. 30 Mar 2009
• TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole. 30 Mar 2009
• Immunogenetics of drug-induced skin blistering disorders. Part I: Perspective. 30 Mar 2009
• Combined effect of IL-10 and TGF-beta1 promoter polymorphisms as a risk factor for aspirin-intolerant asthma and rhinosinusitis. 14 Feb 2009
• Genetic association studies to detect adverse drug reactions: abacavir hypersensitivity as an example. 30 Jan 2009
• Should HLA-B*5701 screening be performed in every ethnic group before starting abacavir? 30 Jan 2009
• Carbamazepine hypersensitivity syndrome triggered by a human herpes virus reactivation in a genetically predisposed patient. 4 Jan 2009
• Gene variants of IL13, IL4, and IL4RA are predictors of beta-lactam allergy. 2009
• Drug rash with eosinophilia and systemic symptoms after penicillin V administration in a patient with acquired C1 inhibitor acquired deficiency. 30 Dec 2008
• HLA-B*5701 screening prior to abacavir prescription: clinical and laboratory aspects. 30 Dec 2008
• Successful translation of pharmacogenetics into the clinic: the abacavir example. 30 Dec 2008

See a longer list of these articles.

Technical information about 'Drug Hypersensitivity'

Definition: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.

Descriptor UI: D004342

Alternative terms: Drug Hypersensitivity; Drug Hypersensitivities; Hypersensitivities, Drug; Drug Allergy; Allergies, Drug; Drug Allergies; Hypersensitivity, Drug; Allergy, Drug;

Allowable Qualifiers: blood; cerebrospinal fluid; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C20.543.206;

History Note: 66; was DRUG ALLERGY 1963-65

Technical Notes: use in conventional sense and not for allergy to every category D term; allergy to non-drug chemical substance=substance /ad eff + HYPERSENSITIVITY or its specifics /etiol; manual 23.24+