Drug Hypersensitivity - Metabolism
Research News and Information

Sunday, November 22, 2009

Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma.

17 Sep 2009 BACKGROUND: NLR family, pyrin domain containing 3 (NLRP3), controls the activity of inflammatory caspase-1 by forming inflammasomes, which leads to cleavage of the procytokines IL-1beta and IL-18. Recent studies have shown associations of human ... Read more...

The basophil activation test in immediate-type drug allergy.

30 Jul 2009 Diagnosis of drug allergy involves first the recognition of sometimes unusual symptoms as drug allergy and, second, the identification of the eliciting drug. This is an often difficult task, as the clinical picture and underlying pathomechanisms are ... Read more...

Chemokine CC-ligand 5 production and eosinophil activation into the upper airways of aspirin-sensitive patients.

8 Feb 2009 BACKGROUND: Airway eosinophilia is a hallmark of aspirin-sensitive asthma/rhinitis. OBJECTIVE: We have investigated chemokine CC-ligand 5 (CCL5) production and its association with eosinophil activation in the upper airways of aspirin-sensitive ... Read more...

Latest indexed articles for 'Drug Hypersensitivity - Metabolism'

These are the very latest articles for this heading:

• Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. 17 Sep 2009
• The basophil activation test in immediate-type drug allergy. 30 Jul 2009
• Chemokine CC-ligand 5 production and eosinophil activation into the upper airways of aspirin-sensitive patients. 8 Feb 2009
• Increased levels of cysteinyl-leukotrienes in saliva, induced sputum, urine and blood from patients with aspirin-intolerant asthma. 27 Aug 2008
• The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity. 30 Jul 2008
• Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity. 30 May 2008
• Involvement of 15-lipoxygenase and prostaglandin EP receptors in aspirin-triggered 15-hydroxyeicosatetraenoic acid generation in aspirin-sensitive asthmatics. 4 May 2008
• [Melatonin expression in nasal polyps in patients with asthmatic triad] 29 Apr 2008
• Allergies to sulfonamide antibiotics and sulfur-containing drugs. 30 Jan 2008
• HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling. 14 Jan 2008
• [Aspirin and other nonsteroidal anti-inflammatory drugs hypersensitivity--mechanisms, diagnostics and treatment] 30 Dec 2007
• IgE-mediated allergy to chlorhexidine. 5 Jun 2007
• Allergen-specific T-cell response in patients with phenytoin hypersensitivity; simultaneous analysis of proliferation and cytokine production by carboxyfluorescein succinimidyl ester (CFSE) dilution assay. 29 Apr 2007
• Immunological principles of T-cell-mediated adverse drug reactions in skin. 27 Feb 2007
• Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage. 30 Dec 2006
• Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. 20 Nov 2006
• Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action. 13 Nov 2006
• Kinin-dependent hypersensitivity reactions in hemodialysis: metabolic and genetic factors. 25 Sep 2006
• Apoptosis induction by retinoids in eosinophilic leukemia cells: implication of retinoic acid receptor-alpha signaling in all-trans-retinoic acid hypersensitivity. 13 Jun 2006
• [Prostaglandin E2: metabolism, determination in body fluids and the role in aspirin hypersensitivity] 30 May 2006

See a longer list of these articles.

Technical information about 'Drug Hypersensitivity'

Definition: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.

Descriptor UI: D004342

Alternative terms: Drug Hypersensitivity; Drug Hypersensitivities; Hypersensitivities, Drug; Drug Allergy; Allergies, Drug; Drug Allergies; Hypersensitivity, Drug; Allergy, Drug;

Allowable Qualifiers: blood; cerebrospinal fluid; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C20.543.206;

History Note: 66; was DRUG ALLERGY 1963-65

Technical Notes: use in conventional sense and not for allergy to every category D term; allergy to non-drug chemical substance=substance /ad eff + HYPERSENSITIVITY or its specifics /etiol; manual 23.24+