Drug Hypersensitivity
Research News and Information

Saturday, November 21, 2009

Genetic effect of CysLTR2 polymorphisms on its mRNA synthesis and stabilization.

18 Oct 2009 BACKGROUND: We previously demonstrated that single nucleotide polymorphism (SNP) and haplotypes were associated with aspirin hypersensitivity in asthmatics. We investigated the genetic effects of the SNPs and haplotypes on the expression of the ... Read more...

Clinicians' assessments of electronic medication safety alerts in ambulatory care.

26 Sep 2009 BACKGROUND: While electronic prescribing (e-prescribing) systems with drug interaction and allergy alerts promise to improve medication safety in ambulatory care, clinicians often override these safety features. We undertook a study of respondents' ... Read more...

Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization.

17 Sep 2009 BACKGROUND: Aspirin-exacerbated respiratory disease is characterized by asthma, nasal polyps, and intolerance to aspirin with overexpression of leukotriene (LT) C(4) synthase and cysteinyl leukotriene receptors. Through an unknown mechanism, aspirin ... Read more...

Latest indexed articles for 'Drug Hypersensitivity'

These are the very latest articles for this heading:

• Anaphylaxis and anesthesia: controversies and new insights. 30 Oct 2009
• Genetic effect of CysLTR2 polymorphisms on its mRNA synthesis and stabilization. 18 Oct 2009
• Clinicians' assessments of electronic medication safety alerts in ambulatory care. 26 Sep 2009
• Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization. 17 Sep 2009
• Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. 17 Sep 2009
• Successful interferon desensitization in a patient with chronic hepatitis C infection. 5 Sep 2009
• Detection of Staphylococcus aureus in nasal tissue with peptide nucleic acid-fluorescence in situ hybridization. 30 Aug 2009
• [Hepatic adverse effects of allopurinol] 30 Aug 2009
• Perioperative antibiotic prophylaxis in adults: the 2008 update of the Italian Guidelines. How can we as anesthetists contribute to the reduction of surgical site infections? 30 Aug 2009
• Is interleukin-2 therapy still a risk factor for adverse reactions in concert with iodinated contrast medium injection? 30 Aug 2009
• Unmet needs in severe chronic upper airway disease (SCUAD). 3 Aug 2009
• Serious adverse drug reaction in a woman with hyperemesis gravidarum after first exposure to vitamin B complex containing vitamins B1, B6 and B12. 30 Jul 2009
• Severe cutaneous reaction following measles immunization. 30 Jul 2009
• Rapid desensitization for hypersensitivity reactions to medications. 30 Jul 2009
• Provocation tests in drug hypersensitivity. 30 Jul 2009
• The basophil activation test in immediate-type drug allergy. 30 Jul 2009
• In vitro tests in drug hypersensitivity diagnosis. 30 Jul 2009
• Skin testing in delayed reactions to drugs. 30 Jul 2009
• Skin testing for IgE-mediated drug allergy. 30 Jul 2009
• The variable clinical picture of drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms in relation to the eliciting drug. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Drug Hypersensitivity'

Definition: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.

Descriptor UI: D004342

Alternative terms: Drug Hypersensitivity; Drug Hypersensitivities; Hypersensitivities, Drug; Drug Allergy; Allergies, Drug; Drug Allergies; Hypersensitivity, Drug; Allergy, Drug;

Allowable Qualifiers: blood; cerebrospinal fluid; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C20.543.206;

History Note: 66; was DRUG ALLERGY 1963-65

Technical Notes: use in conventional sense and not for allergy to every category D term; allergy to non-drug chemical substance=substance /ad eff + HYPERSENSITIVITY or its specifics /etiol; manual 23.24+