Drug Interactions
Research News and Information

Saturday, November 21, 2009

Vincristine: Can its therapeutic index be enhanced?

13 Dec 2009 Vincristine is one of the most widely used and more effective drugs in paediatric oncology. The dose-limiting toxicity of neuropathy, lack of proven neuroprotective measures and an incomplete understanding of the pharmacokinetics and ... Read more...

Positive direct and indirect antiglobulin tests associated with oxaliplatin can be due to drug antibody and/or drug-induced nonimmunologic protein adsorption.

13 Dec 2009 BACKGROUND: Two patients were suspected of having immune hemolytic anemia (IHA) due to oxaliplatin. A related drug, cisplatin, is known to cause nonimmunologic protein adsorption (NIPA). Studies were performed to determine the presence of ... Read more...

Ropivacaine spinal anesthesia is not antagonized by ondansetron pretreatment.

30 Oct 2009 BACKGROUND: We investigated a possible effect of ondansetron on the duration of sensory and motor block produced by ropivacaine. METHODS: Fifty male patients undergoing transurethral surgery received either 8 mg oral ondansetron the evening before ... Read more...

Latest indexed articles for 'Drug Interactions'

These are the very latest articles for this heading:

• Vincristine: Can its therapeutic index be enhanced? 13 Dec 2009
• Aprepitant for the prevention of chemotherapy-induced nausea and vomiting in adolescents. 13 Dec 2009
• Positive direct and indirect antiglobulin tests associated with oxaliplatin can be due to drug antibody and/or drug-induced nonimmunologic protein adsorption. 13 Dec 2009
• Tenofovir coadministration is not associated with lower unboosted atazanavir plasma exposure in the clinical setting. 30 Oct 2009
• Ropivacaine spinal anesthesia is not antagonized by ondansetron pretreatment. 30 Oct 2009
• Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling. 19 Oct 2009
• Recombinant human antithrombin (ATryn). 17 Oct 2009
• Degarelix (firmagon) for prostate cancer. 17 Oct 2009
• Reflections: neurology and the humanities: reflections for October. 11 Oct 2009
• Dronedarone (Multaq) for atrial fibrillation. 3 Oct 2009
• Pregnancy at time of change of Implanon implant. 29 Sep 2009
• EllaOne: a second-generation emergency contraceptive? 29 Sep 2009
• Effects of high plasma fentanyl concentrations on minimum alveolar concentration of isoflurane in horses. 29 Sep 2009
• The clinical efficacy and abuse potential of combination buprenorphine-naloxone in the treatment of opioid dependence. 29 Sep 2009
• QSAR of cytochrome inhibitors. 29 Sep 2009
• Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion. 29 Sep 2009
• Role of GABA transporter 3 in GABAergic synaptic transmission at striatal output neurons. 29 Sep 2009
• The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2(High) receptors. 29 Sep 2009
• Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine. 29 Sep 2009
• N-type calcium channels mediate a GABA(B) presynaptic modulation in the corticostriatal synapse in turtle's paleostriatum augmentatum. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Drug Interactions'

Definition: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.

Descriptor UI: D004347

Alternative terms: Drug Interactions; Drug Interaction; Interaction, Drug; Interactions, Drug;

Related Mesh Headings: Drug Toxicity;

Allowable Qualifiers: ethnology; genetics; immunology; physiology; radiation effects;

Tree Number: G07.690.812.240; G07.700.680.240;

History Note: 72

Technical Notes: do not confuse with DRUG INCOMPATIBILITY; IM when general; NIM with specific drugs (IM)