Drug Screening Assays, Antitumor
Research News and Information

Monday, November 23, 2009

Radiosensitization effect of STI-571 on pancreatic cancer cells in vitro.

30 Oct 2009 PURPOSE: To examine STI-571-induced radiosensitivity in human pancreatic cancer cells in vitro. METHODS AND MATERIALS: Three human pancreatic cancer cell lines (Bxpc-3, Capan-1, and MiaPaCa-2) exhibiting different expression levels of c-Kit and ... Read more...

Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies.

6 Oct 2009 Several small weight indole derivatives (D-64131, D-24851, BPR0L075, BLF 61-3, and ATI derivatives) are potent tubulin polymerization inhibitors and show nanomolar antiproliferative activity. Among them, indolobenzazepin-7-ones were recently ... Read more...

Novel anti-cancer compounds: structure-based discovery of chemical chaperons for p53.

29 Sep 2009 Thermal stability of p53 is crucial in preventing cancer proliferation. Critical mutations which significantly destabilize p53 conformation prevent normal interaction between p53 and DNA and consequently interfere with its inhibitory function ... Read more...

Latest indexed articles for 'Drug Screening Assays, Antitumor'

These are the very latest articles for this heading:

• Radiosensitization effect of STI-571 on pancreatic cancer cells in vitro. 30 Oct 2009
• High-throughput screening finds potential killer of cancer stem cells. 12 Oct 2009
• Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies. 6 Oct 2009
• Novel anti-cancer compounds: structure-based discovery of chemical chaperons for p53. 29 Sep 2009
• Initial testing (stage 1) of lapatinib by the pediatric preclinical testing program. 29 Sep 2009
• Flow cytometric chemosensitivity assay as a predictive tool of early clinical response in acute lymphoblastic leukemia. 29 Sep 2009
• Evaluation of molecular descriptors for antitumor drugs with respect to noncovalent binding to DNA and antiproliferative activity. 14 Sep 2009
• Leucophyllidine, a cytotoxic bisindole alkaloid constituted from the union of an eburnan and a new vinylquinoline alkaloid. Sep 2009
• Effect of melatonin on melanoma cells subjected to UVA and UVB radiation in In vitro studies. 30 Aug 2009
• Modelling of tumour--host coexistence In vitro in the presence of serine protease inhibitors. 30 Aug 2009
• [Upper G.I. cancer: the esophagus and stomach cancers. I. The current status of tests for anti-cancer agent sensitivity: in memory of Prof. Tetsuro Kubota] 30 Aug 2009
• Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula. 30 Aug 2009
• Isolation and structural elucidation of euryjanicins B-D, proline-containing cycloheptapeptides from the Caribbean marine sponge Prosuberites laughlini. 30 Aug 2009
• Bioactive guanidine alkaloids from two Caribbean marine sponges. 30 Aug 2009
• Alkaloids from the leaves of Daphniphyllum subverticillatum. 30 Aug 2009
• Gamma-lactones and ent-eudesmane sesquiterpenes from the endophytic fungus Eutypella sp. BCC 13199. 30 Aug 2009
• Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. 30 Aug 2009
• Antiproliferative triterpenoid saponins of Dodonaea viscosa from the Madagascar dry forest. 30 Aug 2009
• Biscarpamontamines A and B, an aspidosperma-iboga bisindole alkaloid and an aspidosperma-aspidosperma bisindole alkaloid, from Tabernaemontana sphaerocarpa. 30 Aug 2009
• Spirobisnaphthalene analogues from the endophytic fungus Preussia sp. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Drug Screening Assays, Antitumor'

Definition: Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

Descriptor UI: D004354

Alternative terms: Drug Screening Assays, Antitumor; Anticancer Drug Sensitivity Tests; Cancer Drug Tests; Cancer Drug Test; Drug Test, Cancer; Drug Tests, Cancer; Test, Cancer Drug; Tests, Cancer Drug; Antitumor Drug Screens; Antitumor Drug Screen; Drug Screen, Antitumor; Drug Screens, Antitumor; Screen, Antitumor Drug; Screens, Antitumor Drug; Drug Screening Tests, Tumor-Specific; Drug Screening Tests, Tumor Specific; Tumor-Specific Drug Screening Tests; Tumor Specific Drug Screening Tests; Anti-Cancer Drug Screens; Anti Cancer Drug Screens; Anti-Cancer Drug Screen; Drug Screen, Anti-Cancer; Drug Screens, Anti-Cancer; Screen, Anti-Cancer Drug; Screens, Anti-Cancer Drug; Antitumor Drug Screening Assays; Dye Exclusion Assays, Antitumor;

Allowable Qualifiers: classification; economics; history; instrumentation; methods; standards; trends; utilization; veterinary; statistics & numerical data; ethics;

Tree Number: E05.200.500.388; E05.337.550.200;

History Note: 88

Technical Notes: IM when general; NIM when with specific antineoplastic agent (IM)