Endocannabinoids
Research News and Information

Sunday, November 22, 2009

Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation.

30 Oct 2009 We tested the hypothesis that increased dopaminergic sensitivity induced by olfactory bulbectomy is mediated by dysregulation of endocannabinoid signaling. Bilateral olfactory bulbectomy induces behavioral and neurobiological symptomatology related ... Read more...

Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities.

19 Oct 2009 Homeostatic regulation of synaptic strength in response to persistent changes of neuronal activity plays an important role in maintaining the overall level of circuit activity within a normal range. Absence of miniature EPSCs (mEPSCs) for a few ... Read more...

Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects.

8 Sep 2009 OBJECTIVE: Endocannabinoids (ECs) control metabolism via cannabinoid receptors type 1 (CB1). Their plasma levels are elevated in overweight type 2 diabetes (T2D) and in obese patients, and decrease postprandially in normoweight individuals. We ... Read more...

Latest indexed articles for 'Endocannabinoids'

These are the very latest articles for this heading:

• Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation. 30 Oct 2009
• Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. 19 Oct 2009
• Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects. 8 Sep 2009
• Cannabinoids for clinicians: the rise and fall of the cannabinoid antagonists. Sep 2009
• The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants. Sep 2009
• Dual modulation of CNS voltage-gated calcium channels by cannabinoids: Focus on CB1 receptor-independent effects. 11 Aug 2009
• Anandamide increases swelling and reduces calcium sensitivity of mitochondria. 9 Aug 2009
• Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization. 5 Aug 2009
• Cannabinoid system in the skin - a possible target for future therapies in dermatology. 30 Jul 2009
• Sleep-inducing factors. 30 Jul 2009
• Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice. 30 Jul 2009
• Endocannabinoids and cardiac contractile function: pathophysiological implications. 30 Jul 2009
• Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling. 30 Jul 2009
• Metabolism of anandamide by COX-2 is necessary for endocannabinoid-induced cell death in tumorigenic keratinocytes. 30 Jul 2009
• Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. 29 Jul 2009
• Chronic ethanol treatment potentiates ethanol-induced increases in interstitial nucleus accumbens endocannabinoid levels in rats. 21 Jul 2009
• The endocannabinoid transport inhibitor AM404 modulates nociception in cholestasis. 14 Jul 2009
• Characterization of the endocannabinoid system in human spermatozoa and involvement of transient receptor potential vanilloid 1 receptor in their fertilizing ability. 14 Jul 2009
• The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. 12 Jul 2009
• Endocannabinoids suppress excitatory synaptic transmission to dorsal raphe serotonin neurons through the activation of presynaptic CB1 receptors. 8 Jul 2009

See a longer list of these articles.

Technical information about 'Endocannabinoids'

Definition: Endogenous compounds that bind to CANNABINOID RECEPTORS. They are structurally different from the CANNABINOIDS which are primarily derived from plants.

Registry Number: 0

Descriptor UI: D043883

Alternative terms: Endocannabinoids; Endogenous Cannabinoids; Endocannabinoid; Cannabinoid Receptor Modulators; Modulators, Cannabinoid Receptor; Receptor Modulators, Cannabinoid; Cannabinoids, Endogenous;

Related Mesh Headings: Cannabinoids; Receptors, Cannabinoid;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.519.625.170; D27.505.696.399.472.215;

History Note: 2004; use ENDOCANNABINOIDS (NM) 2002-2003