Endoribonucleases - Metabolism
Research News and Information

Sunday, November 22, 2009

Reconstituting bacterial RNA repair and modification in vitro.

7 Oct 2009 Ribotoxins kill cells by endonucleotically cleaving essential RNAs involved in protein translation. We report here that a stable heterotetramer composed of two bacterial proteins, Pnkp and Hen1, was able to repair transfer RNAs cleaved by ribotoxins ... Read more...

Human cytosolic tRNase ZL can downregulate gene expression through miRNA.

10 Sep 2009 A long form of tRNase Z (tRNase ZL) can cleave any target RNA at any desired site under the direction of artificial small guide RNA including approximately 25-nucleotide hook-shaped RNA. Here we show that human miR-103 can form a hook structure to ... Read more...

Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome.

9 Sep 2009 Endoplasmic reticulum (ER) stress is a hallmark feature of secretory cells and many diseases, including cancer, neurodegeneration, and diabetes. Adaptation to protein-folding stress is mediated by the activation of an integrated signal transduction ... Read more...

Latest indexed articles for 'Endoribonucleases - Metabolism'

These are the very latest articles for this heading:

• Reconstituting bacterial RNA repair and modification in vitro. 7 Oct 2009
• Human cytosolic tRNase ZL can downregulate gene expression through miRNA. 10 Sep 2009
• Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. 9 Sep 2009
• Transcriptional regulation of the Escherichia coli gene rraB, encoding a protein inhibitor of RNase E. 26 Aug 2009
• Functional conservation of tRNase ZL among Saccharomyces cerevisiae, Schizosaccharomyces pombe and humans. 25 Aug 2009
• Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress- and calpain-mediated mitochondrial cell death pathways. 18 Aug 2009
• The African swine fever virus g5R protein possesses mRNA decapping activity. 17 Aug 2009
• Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. 14 Aug 2009
• IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. 5 Aug 2009
• Kill the messenger: bacterial antisense RNA promotes mRNA decay. 30 Jul 2009
• Conserved and variable domains of RNase MRP RNA. 28 Jul 2009
• Bacillus subtilis trp Leader RNA: RNase J1 endonuclease cleavage specificity and PNPase processing. 26 Jul 2009
• Lsm1-7-Pat1 complex: a link between 3' and 5'-ends in mRNA decay? 22 Jul 2009
• Significant bias against the ACA triplet in the tmRNA sequence of Escherichia coli K-12. 22 Jul 2009
• Ribosomal protein mRNAs are primary targets of regulation in RNase-L-induced senescence. 21 Jul 2009
• Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates. 21 Jul 2009
• Leucyl-tRNA synthetase-dependent and -independent activation of a group I intron. 19 Jul 2009
• Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation. 18 Jul 2009
• The virion-packaged endoribonuclease of herpes simplex virus 1 cleaves mRNA in polyribosomes. 5 Jul 2009
• In vitro characterization of a miR-122-sensitive double-helical switch element in the 5' region of hepatitis C virus RNA. Jul 2009

See a longer list of these articles.

Technical information about 'Endoribonucleases'

Definition: A family of enzymes that catalyze the endonucleolytic cleavage of RNA. It includes EC 3.1.26.-, EC 3.1.27.-, EC 3.1.30.-, and EC 3.1.31.-.

Registry Number: EC 3.1.-

Descriptor UI: D004722

Alternative terms: Endoribonucleases;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.277.352.355.350; D08.811.277.352.700.350;

History Note: 83