Endoribonucleases
Research News and Information

Sunday, November 22, 2009

Reconstituting bacterial RNA repair and modification in vitro.

7 Oct 2009 Ribotoxins kill cells by endonucleotically cleaving essential RNAs involved in protein translation. We report here that a stable heterotetramer composed of two bacterial proteins, Pnkp and Hen1, was able to repair transfer RNAs cleaved by ribotoxins ... Read more...

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy.

15 Sep 2009 Mutations in superoxide dismutase-1 (SOD1) cause familial amyotrophic lateral sclerosis (fALS). Recent evidence implicates adaptive responses to endoplasmic reticulum (ER) stress in the disease process via a pathway known as the unfolded protein ... Read more...

Human cytosolic tRNase ZL can downregulate gene expression through miRNA.

10 Sep 2009 A long form of tRNase Z (tRNase ZL) can cleave any target RNA at any desired site under the direction of artificial small guide RNA including approximately 25-nucleotide hook-shaped RNA. Here we show that human miR-103 can form a hook structure to ... Read more...

Latest indexed articles for 'Endoribonucleases'

These are the very latest articles for this heading:

• Reconstituting bacterial RNA repair and modification in vitro. 7 Oct 2009
• XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. 15 Sep 2009
• Human cytosolic tRNase ZL can downregulate gene expression through miRNA. 10 Sep 2009
• Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. 9 Sep 2009
• XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors. 6 Sep 2009
• Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development. 30 Aug 2009
• Transcriptional regulation of the Escherichia coli gene rraB, encoding a protein inhibitor of RNase E. 26 Aug 2009
• Functional conservation of tRNase ZL among Saccharomyces cerevisiae, Schizosaccharomyces pombe and humans. 25 Aug 2009
• An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. 21 Aug 2009
• Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress- and calpain-mediated mitochondrial cell death pathways. 18 Aug 2009
• The African swine fever virus g5R protein possesses mRNA decapping activity. 17 Aug 2009
• Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. 14 Aug 2009
• IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. 5 Aug 2009
• Kill the messenger: bacterial antisense RNA promotes mRNA decay. 30 Jul 2009
• Conserved and variable domains of RNase MRP RNA. 28 Jul 2009
• Bacillus subtilis trp Leader RNA: RNase J1 endonuclease cleavage specificity and PNPase processing. 26 Jul 2009
• Lsm1-7-Pat1 complex: a link between 3' and 5'-ends in mRNA decay? 22 Jul 2009
• Significant bias against the ACA triplet in the tmRNA sequence of Escherichia coli K-12. 22 Jul 2009
• Ribosomal protein mRNAs are primary targets of regulation in RNase-L-induced senescence. 21 Jul 2009
• Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates. 21 Jul 2009

See a longer list of these articles.

Technical information about 'Endoribonucleases'

Definition: A family of enzymes that catalyze the endonucleolytic cleavage of RNA. It includes EC 3.1.26.-, EC 3.1.27.-, EC 3.1.30.-, and EC 3.1.31.-.

Registry Number: EC 3.1.-

Descriptor UI: D004722

Alternative terms: Endoribonucleases;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.277.352.355.350; D08.811.277.352.700.350;

History Note: 83