Enkephalin, Ala(2)-MePhe(4)-Gly(5)- - Pharmacology
Research News and Information

Sunday, November 22, 2009

Behavioral characterization of amygdala involvement in mediating intra-accumbens opioid-driven feeding behavior.

30 Jul 2009 The present experiments were conducted to provide a more detailed behavioral analysis of the dissociable roles of the basolateral (BLA) and central nucleus (CeA) of the amygdala in mediating intra-accumbens (Acb) opioid-induced feeding of a high-fat ... Read more...

Opioid mu-receptors in medullary raphe region affect the hypoxic ventilation in anesthetized rats.

22 Jul 2009 Opioids can attenuate the peripheral chemoreceptor-mediated hypoxic ventilatory response (HVR) by acting on central mu-type opioid receptors. Since the medullary raphe region (MRR) expresses abundant mu-receptors and participates in modulating HVR, ... Read more...

Induction of synaptic long-term potentiation after opioid withdrawal.

8 Jul 2009 mu-Opioid receptor (MOR) agonists represent the gold standard for the treatment of severe pain but may paradoxically also enhance pain sensitivity, that is, lead to opioid-induced hyperalgesia (OIH). We show that abrupt withdrawal from MOR agonists ... Read more...

Latest indexed articles for 'Enkephalin, Ala(2)-MePhe(4)-Gly(5)- - Pharmacology'

These are the very latest articles for this heading:

• Behavioral characterization of amygdala involvement in mediating intra-accumbens opioid-driven feeding behavior. 30 Jul 2009
• Opioid mu-receptors in medullary raphe region affect the hypoxic ventilation in anesthetized rats. 22 Jul 2009
• Induction of synaptic long-term potentiation after opioid withdrawal. 8 Jul 2009
• Involvement of Ca2+-dependent PKCs in the adaptive changes of mu-opioid pathways to sympathetic denervation in the guinea pig colon. 6 Jul 2009
• Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. 17 Jun 2009
• Functional characterization of human variants of the mu-opioid receptor gene. 13 Jun 2009
• Regulation of interleukin-1beta and interleukin-8 production by agonists of mu and delta opiate receptors in vitro. 9 Jun 2009
• Which cue to "want?" Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cue. 18 May 2009
• Capsaicin-evoked iCGRP release from human dental pulp: a model system for the study of peripheral neuropeptide secretion in normal healthy tissue. 7 May 2009
• Inhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways. 6 May 2009
• Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells. 3 May 2009
• Activating mu-opioid receptors in the lateral parabrachial nucleus increases c-Fos expression in forebrain areas associated with caloric regulation, reward and cognition. 3 May 2009
• Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons. 6 Apr 2009
• [Mu-opioidergic immunomodulation: the neurochemical basis] 30 Mar 2009
• Shadows across mu-Star? Constitutively active mu-opioid receptors revisited. 30 Mar 2009
• Activation of mu-opioid receptors in thalamic nucleus submedius depresses bee venom-evoked spinal c-Fos expression and flinching behavior. 29 Mar 2009
• Seizure activity involved in the up-regulation of BDNF mRNA expression by activation of central mu opioid receptors. 17 Mar 2009
• Functional interaction between TRPV1 and micro-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia. 16 Mar 2009
• Role of mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior. 9 Mar 2009
• Persistent inflammatory pain decreases the antinociceptive effects of the mu opioid receptor agonist DAMGO in the locus coeruleus of male rats. Mar 2009

See a longer list of these articles.

Technical information about 'Enkephalin, Ala(2)-MePhe(4)-Gly(5)-'

Definition: An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.

Chemical name: L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-nalpha-methyl-

Registry Number: 100929-53-1

Descriptor UI: D020875

Alternative terms: Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Tyr-Ala-Gly-(NMe)Phe-Gly-ol; 2-Ala-4-MePhe-5-Gly-Enkephalin; 2 Ala 4 MePhe 5 Gly Enkephalin; Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin; D-Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin; DAMGO; DAGO; DAGOL; DAMGE; Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-; D-Ala2-NMe-Phe4-Gly-ol Enkephalin; D Ala2 NMe Phe4 Gly ol Enkephalin; Enkephalin, D-Ala2-NMe-Phe4-Gly-ol; RX-783006; RX 783006;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Anti-Arrhythmia Agents; Neurotransmitter Agents; Analgesics, Opioid;

Tree Number: D12.644.400.575.281.075; D12.644.468.281.075; D12.776.641.650.575.281.075;

History Note: 2000; use ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)- (NM) 1981-1999