Enkephalins - Genetics
Research News and Information

Monday, November 23, 2009

Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats.

25 Aug 2009 We investigated the effect of early vs. late initiation of levodopa treatment on dyskinetic movements, rotational behavior and molecular markers in hemiparkinsonian rats. Male Sprague-Dawley rats received a unilateral 6-hydroxydopamine (6-OHDA) ... Read more...

Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice.

29 Jun 2009 The delta opioid system is involved in the behavioral effects of various drugs of abuse. However, only a few studies have focused on the possible interactions between the opioid system and the effects of 3,4-methylenedioxymethamphetamine (MDMA). In ... Read more...

Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice.

23 Jun 2009 Dynorphin is the presumed endogenous ligand for the kappa-opioid receptor. The dynorphin gene may play a role in psychotropic agent-mediated behavioral changes via dopaminergic modulation. Therefore, in this study, possible involvement of the ... Read more...

Latest indexed articles for 'Enkephalins - Genetics'

These are the very latest articles for this heading:

• Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats. 25 Aug 2009
• Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice. 29 Jun 2009
• Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice. 23 Jun 2009
• Developmental changes in the mRNA expression of neuropeptides and dopamine and glutamate receptors in neonates and adult rats after ventral hippocampal lesion. 2 Jun 2009
• Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP. Jun 2009
• Puberty onset in female rats: relationship with fat intake, ovarian steroids and the peptides, galanin and enkephalin, in the paraventricular and medial preoptic nuclei. 30 May 2009
• Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly. 24 May 2009
• Endogenous kappa opioid activation mediates stress-induced deficits in learning and memory. 30 Mar 2009
• Differential regulation of prodynophin, c-fos, and serotonin transporter mRNA following withdrawal from a chronic, escalating dose regimen of D-amphetamine. 30 Mar 2009
• D2R striatopallidal neurons inhibit both locomotor and drug reward processes. 6 Mar 2009
• An association of prodynorphin polymorphisms and opioid dependence in females in a Chinese population. 3 Mar 2009
• The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning. 15 Feb 2009
• Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes? 20 Jan 2009
• Candidate genes for temporal lobe epilepsy: a replication study. 4 Dec 2008
• The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins. 3 Dec 2008
• Effect of methamphetamine neurotoxicity on learning-induced Arc mRNA expression in identified striatal efferent neurons. 29 Nov 2008
• The expression of genes coding for opioid precursors, opioid receptors, beta-LH subunit and GnRH receptor in the anterior pituitary of cyclic gilts. 29 Nov 2008
• Changes in prodynorphin gene expression and neuronal morphology in the hypothalamus of postmenopausal women. 29 Nov 2008
• Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease. 4 Nov 2008
• Dynamic of migration of HSV-1 from a medullary pronociceptive centre: antinociception by overexpression of the preproenkephalin transgene. 30 Oct 2008

See a longer list of these articles.

Technical information about 'Enkephalins'

Definition: One of the three major families of endogenous opioid peptides. The enkephalins are pentapeptides that are widespread in the central and peripheral nervous systems and in the adrenal medulla.

Registry Number: 0

Descriptor UI: D004745

Alternative terms: Enkephalins; Enkephalin;

Related Mesh Headings: Receptors, Opioid;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Neurotransmitter Agents;

Tree Number: D12.644.400.575.281; D12.644.468.281; D12.776.641.650.575.281;

History Note: 83(Aug 77); was see under ENDORPHINS Aug 1977-82

Technical Notes: general or unspecified; prefer specifics