Enzyme Activation - Physiology
Research News and Information

Monday, March 15, 2010

Retinotopic mapping requires focal adhesion kinase-mediated regulation of growth cone adhesion.

2 Nov 2009 Adhesion controls growth cone motility, yet the effects of axon guidance cues on adhesion site dynamics are poorly understood. Here we show that ephrin-A1 reduces retinal ganglion cell (RGC) axon outgrowth by stabilizing existing adhesions and ... Read more...

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.

2 Nov 2009 Leucine-rich repeat kinase 2 (LRRK2) functions as a putative protein kinase of ezrin, radixin, and moesin (ERM) family proteins. A Parkinson's disease-related G2019S substitution in the kinase domain of LRRK2 further enhances the phosphorylation of ... Read more...

Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation.

2 Nov 2009 The goal of this study was to elucidate the mechanisms of 17beta-estradiol (E(2)) antioxidant and neuroprotective actions in stroke. The results reveal a novel extranuclear receptor-mediated antioxidant mechanism for E(2) during stroke, as well as a ... Read more...

Latest indexed articles for 'Enzyme Activation - Physiology'

These are the very latest articles for this heading:

• Retinotopic mapping requires focal adhesion kinase-mediated regulation of growth cone adhesion. 2 Nov 2009
• Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. 2 Nov 2009
• Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation. 2 Nov 2009
• p38 Mitogen-activated protein kinase and hematologic malignancies. 30 Oct 2009
• Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis. 29 Sep 2009
• The C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity. 23 Sep 2009
• Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30. 7 Sep 2009
• Angiotensin II type-1 receptor regulates RhoA and Rho-kinase/ROCK activation via multiple mechanisms. Focus on "Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells". 7 Sep 2009
• Caspase-9 activation revealed by semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb. 7 Sep 2009
• 17beta-Estradiol regulates the first steps of skeletal muscle cell differentiation via ER-alpha-mediated signals. 31 Aug 2009
• The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor. 31 Aug 2009
• c-Jun N-terminal kinase pathway activation in human and experimental cerebral contusion. 30 Aug 2009
• Yersinia pseudotuberculosis virulence determinants invasin, YopE, and YopT modulate RhoG activity and localization. 29 Aug 2009
• An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms. 23 Aug 2009
• Francisella tularensis induces extensive caspase-3 activation and apoptotic cell death in the tissues of infected mice. 22 Aug 2009
• Dexamethasone decreases neuronal nitric oxide release in mesenteric arteries from hypertensive rats through decreased protein kinase C activation. 22 Aug 2009
• Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury. 18 Aug 2009
• Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells. 17 Aug 2009
• The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases. 11 Aug 2009
• Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1. 11 Aug 2009

See a longer list of these articles.

Technical information about 'Enzyme Activation'

Definition: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.

Descriptor UI: D004789

Alternative terms: Enzyme Activation; Activation, Enzyme; Activations, Enzyme; Enzyme Activations;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G02.111.087.245; G02.149.115.245; G03.495.368;

History Note: 76(69); was see under BIOCHEMISTRY 1975

Technical Notes: IM for general only; NIM with specific enzyme (IM); "enzyme reactivation": coord IM with specific enzyme /metab (IM) + ENZYME REACTIVATORS (IM) if discussed (see note there)