Enzyme Induction - Drug effects
Research News and Information

Sunday, November 22, 2009

Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism.

2 Sep 2009 Oxidative stress plays an important role in the pathogenesis of pulmonary fibrosis. Heme oxygenase-1 (HO-1) is a key antioxidant enzyme, and overexpression of HO-1 significantly decreases lung inflammation and fibrosis in animal models. Peroxisome ... Read more...

Should enzyme-inducing antiepileptic drugs be considered first-line agents?

30 Aug 2009 Despite the introduction of a host of new antiepileptic drugs (AEDs) over the last 20 years, the older agents, which are potent inducers of the cytochrome P450 (CYP450) system, remain the AEDs most commonly prescribed throughout the world. At the ... Read more...

Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element.

16 Aug 2009 Identifying agents that block tumor initiation is a goal of cancer prevention. The ability of a chemically varied group of agents to induce various drug metabolizing genes in livers of rats was examined. Sprague-Dawley rats were treated for 7 days ... Read more...

Latest indexed articles for 'Enzyme Induction - Drug effects'

These are the very latest articles for this heading:

• Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism. 2 Sep 2009
• Should enzyme-inducing antiepileptic drugs be considered first-line agents? 30 Aug 2009
• Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element. 16 Aug 2009
• More feedback on whether atrazine is a potent endocrine disruptor chemical. 13 Aug 2009
• Human haem oxygenase-1 induction by nitro-linoleic acid is mediated by cAMP, AP-1 and E-box response element interactions. 11 Aug 2009
• Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. 9 Aug 2009
• Induction of MMP-1 (collagenase-1) by relaxin in fibrocartilaginous cells requires both the AP-1 and PEA-3 promoter sites. 30 Jul 2009
• Influence of aroclor 1254 on benzo(a)pyrene-induced DNA breakage, oxidative DNA damage, and cytochrome P4501A activity in human hepatoma cell line. 30 Jul 2009
• Nuclear receptors: the controlling force in drug metabolism of the liver? 30 Jul 2009
• Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation. 30 Jul 2009
• Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1. 21 Jul 2009
• Technical pentabromodiphenyl ether and hexabromocyclododecane as activators of the pregnane-X-receptor (PXR). 21 Jul 2009
• Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein. 14 Jul 2009
• Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. 8 Jul 2009
• Heme oxygenase: the key to renal function regulation. 29 Jun 2009
• Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction. 29 Jun 2009
• Dissecting the regulation of fructan metabolism in chicory (Cichorium intybus) hairy roots. 24 Jun 2009
• Heme oxygenase-1 increases endothelial progenitor cells. 16 Jun 2009
• Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells. 15 Jun 2009
• Tranexamic acid protects against rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells. 14 Jun 2009

See a longer list of these articles.

Technical information about 'Enzyme Induction'

Definition: An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.

Descriptor UI: D004790

Alternative terms: Enzyme Induction; Induction, Enzyme;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G05.355.315.320.200;

History Note: 68(66)

Technical Notes: IM for general only; NIM with specific enzyme /biosyn (IM)