Enzyme Induction
Research News and Information

Sunday, November 22, 2009

Role of p38 MAPK pathway in induction of iNOS expression in neutrophils and peripheral blood mononuclear cells in patients with squamous cell carcinoma of the oral cavity.

30 Oct 2009 PURPOSE: The aim of the present study was to assess the role of the p38 mitogen-activated protein kinase (MAPK) pathway in the induction of inducible nitric oxide synthase (iNOS) expression and the production of NO by neutrophils (polymorphonuclear ... Read more...

Involvement of cytosolic phospholipase A2alpha in MMP-9 up-regulation.

30 Oct 2009 Matrix metalloproteinase-9 (MMP-9) is important in the pathogenesis of periodontitis. Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is involved in MMP-9 up-regulation in human monocytes. We tested the hypothesis that cPLA(2)alpha also regulates ... Read more...

Correlation of enzyme-inducing anticonvulsant use with outcome of patients with glioblastoma.

11 Oct 2009 BACKGROUND: Clinical trials involving patients with glioblastoma (GBM) distinguish cohorts who are treated with enzyme-inducing anticonvulsants (EIAC). Such anticonvulsants induce hepatic P450 microsomal enzymes, which accelerate the metabolism of ... Read more...

Latest indexed articles for 'Enzyme Induction'

These are the very latest articles for this heading:

• Role of p38 MAPK pathway in induction of iNOS expression in neutrophils and peripheral blood mononuclear cells in patients with squamous cell carcinoma of the oral cavity. 30 Oct 2009
• Involvement of cytosolic phospholipase A2alpha in MMP-9 up-regulation. 30 Oct 2009
• Correlation of enzyme-inducing anticonvulsant use with outcome of patients with glioblastoma. 11 Oct 2009
• Brain CYP1A in seabream, Sparus aurata exposed to benzo(a)pyrene. 29 Sep 2009
• Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits. 23 Sep 2009
• Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism. 2 Sep 2009
• Should enzyme-inducing antiepileptic drugs be considered first-line agents? 30 Aug 2009
• Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells. 26 Aug 2009
• Eukaryotic initiation factor 4a3 is a selenium-regulated RNA-binding protein that selectively inhibits selenocysteine incorporation. 26 Aug 2009
• Kinky binding and SECsy insertions. 26 Aug 2009
• Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element. 16 Aug 2009
• More feedback on whether atrazine is a potent endocrine disruptor chemical. 13 Aug 2009
• Human haem oxygenase-1 induction by nitro-linoleic acid is mediated by cAMP, AP-1 and E-box response element interactions. 11 Aug 2009
• Oxidative stress and hypoxia contribute to Alzheimer's disease pathogenesis: two sides of the same coin. 9 Aug 2009
• Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. 9 Aug 2009
• Identification of two glucocorticoid response elements in the promoter region of the ubiquitous isoform of glutamine synthetase in gulf toadfish, Opsanus beta. 3 Aug 2009
• Induction of hepatic cyclooxygenase-2 by hyperhomocysteinemia via nuclear factor-kappaB activation. 3 Aug 2009
• Induction of MMP-1 (collagenase-1) by relaxin in fibrocartilaginous cells requires both the AP-1 and PEA-3 promoter sites. 30 Jul 2009
• Influence of aroclor 1254 on benzo(a)pyrene-induced DNA breakage, oxidative DNA damage, and cytochrome P4501A activity in human hepatoma cell line. 30 Jul 2009
• Nuclear receptors: the controlling force in drug metabolism of the liver? 30 Jul 2009

See a longer list of these articles.

Technical information about 'Enzyme Induction'

Definition: An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.

Descriptor UI: D004790

Alternative terms: Enzyme Induction; Induction, Enzyme;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G05.355.315.320.200;

History Note: 68(66)

Technical Notes: IM for general only; NIM with specific enzyme /biosyn (IM)