Enzyme Inhibitors - Pharmacology
Research News and Information

Saturday, November 21, 2009

Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval.

29 Nov 2009 ClC-2 chloride channel is present in the brain and some transporting epithelia where its function is poorly understood. We have now demonstrated that the surface channels are rapidly internalised and approximately the 70% of the surface membrane ... Read more...

Ceramide metabolism determines glioma cell resistance to chemotherapy.

29 Nov 2009 Tumor cell resistance to chemotherapy constitutes a major problem in the treatment of malignant tumors. We here investigated the role of ceramide metabolism for the resistance of glioma cells to treatment with the chemotherapeutic drug, gemcitabine. ... Read more...

PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc.

29 Nov 2009 The goal of the investigation was to test the hypothesis that the phosphoinositide-3 kinase (PI3K)/AKT signaling pathway regulates the expression of the major extracellular matrix component of the intervertebral disc, aggrecan, in nucleus pulposus ... Read more...

Latest indexed articles for 'Enzyme Inhibitors - Pharmacology'

These are the very latest articles for this heading:

• Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval. 29 Nov 2009
• Ceramide metabolism determines glioma cell resistance to chemotherapy. 29 Nov 2009
• PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc. 29 Nov 2009
• Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase. 15 Nov 2009
• Kinetic mechanism and inhibitor characterization of WNK1 kinase. Nov 2009
• Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival. 30 Oct 2009
• Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons. 30 Oct 2009
• Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation. 30 Oct 2009
• New biochemical approaches towards understanding the Parkinson's disease-associated kinase, LRRK2. 21 Oct 2009
• Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. 21 Oct 2009
• Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. 19 Oct 2009
• The TC10-Exo70 complex is essential for membrane expansion and axonal specification in developing neurons. 19 Oct 2009
• Nitric oxide potentiation of locomotor activity in the spinal cord of the lamprey. 19 Oct 2009
• Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord. 19 Oct 2009
• Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. 19 Oct 2009
• Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue. 18 Oct 2009
• Characterization of the CHK1 allosteric inhibitor binding site. 18 Oct 2009
• Bestrophin-1 encodes for the Ca2+-activated anion channel in hippocampal astrocytes. 12 Oct 2009
• Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. 12 Oct 2009
• Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. 6 Oct 2009

See a longer list of these articles.

Technical information about 'Enzyme Inhibitors'

Definition: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Registry Number: 0

Descriptor UI: D004791

Alternative terms: Enzyme Inhibitors; Inhibitors, Enzyme;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.519.389;

Online Note: search ENZYMES /AI 1968-74 & ENZYMES 1966-67

History Note: 75,64-67

Technical Notes: GEN only; prefer specifics