Enzymes - Metabolism
Research News and Information

Saturday, November 21, 2009

Modeling the syn disposition of nitrogen donors in non-heme diiron enzymes. Synthesis, characterization, and hydrogen peroxide reactivity of diiron(III) complexes with the syn N-donor ligand H2BPG2DEV.

12 Oct 2009 In order to model the syn disposition of histidine residues in carboxylate-bridged non-heme diiron enzymes, we prepared a new dinucleating ligand, H(2)BPG(2)DEV, that provides this geometric feature. The ligand incorporates biologically relevant ... Read more...

Reactome array: forging a link between metabolome and genome.

7 Oct 2009 We describe a sensitive metabolite array for genome sequence-independent functional analysis of metabolic phenotypes and networks, the reactomes, of cell populations and communities. The array includes 1676 dye-linked substrate compounds ... Read more...

Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress.

29 Sep 2009 The enhanced oxidative stress associated with type 2 diabetes mellitus contributes to disease pathogenesis. We previously identified plasma membrane-associated ATP-sensitive K+ (KATP) channels of pancreatic beta cells as targets for oxidants. Here, ... Read more...

Latest indexed articles for 'Enzymes - Metabolism'

These are the very latest articles for this heading:

• Modeling the syn disposition of nitrogen donors in non-heme diiron enzymes. Synthesis, characterization, and hydrogen peroxide reactivity of diiron(III) complexes with the syn N-donor ligand H2BPG2DEV. 12 Oct 2009
• Reactome array: forging a link between metabolome and genome. 7 Oct 2009
• Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress. 29 Sep 2009
• Magnetic enzyme carrier for effective biofouling control in the membrane bioreactor based on enzymatic quorum quenching. 29 Sep 2009
• Metabolomics for biotransformations: Intracellular redox cofactor analysis and enzyme kinetics offer insight into whole cell processes. 29 Sep 2009
• Enzyme millisecond conformational dynamics do not catalyze the chemical step. 23 Sep 2009
• Single DNA/protein studies with magnetic traps. 21 Sep 2009
• Three-dimensional structural view of the central metabolic network of Thermotoga maritima. 16 Sep 2009
• Bio-oxidation of terpenes: an approach for the flavor industry. 30 Aug 2009
• Origin of life on earth. 30 Aug 2009
• Simplified yet highly accurate enzyme kinetics for cases of low substrate concentrations. 26 Aug 2009
• EnzyMiner: automatic identification of protein level mutations and their impact on target enzymes from PubMed abstracts. 25 Aug 2009
• A mapping of drug space from the viewpoint of small molecule metabolism. 19 Aug 2009
• Multienzyme complexes and hydrogen transfer: the work of Perry Frey. 19 Aug 2009
• Defining network topologies that can achieve biochemical adaptation. 19 Aug 2009
• Next generation chemical proteomic tools for rapid enzyme profiling. 16 Aug 2009
• Role of conformational dynamics in kinetics of an enzymatic cycle in a nonequilibrium steady state. 12 Aug 2009
• Design of functional metalloproteins. 11 Aug 2009
• Mechanistic considerations of halogenating enzymes. 11 Aug 2009
• Molybdenum cofactors, enzymes and pathways. 11 Aug 2009

See a longer list of these articles.

Technical information about 'Enzymes'

Definition: Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.

Registry Number: 0

Descriptor UI: D004798

Alternative terms: Enzymes; Biocatalysts;

Related Mesh Headings: Substrate Specificity;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811;

Online Note: pre-explosion = ENZYMES (PX)

Technical Notes: general only: avoid; prefer specific enzyme or / enzymol: Manual 19.7+, 19.8.30; policy: Manual 25.18+; SUBSTRATE SPECIFICITY, restricted to enzymes, is available; ENZYME TESTS, CLINICAL is available for measuring the level of a specific enzyme in the diagnosis of a disease; ENZYME ACTIVATION, ENZYME REPRESSION, ENZYME SATABILITY are also available; ENZYME INDUCTION: coordinate with specific enzyme / biosyn