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Ephrins - Metabolism
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Definition of 'Ephrins'

Signaling proteins that are ligands for the EPH FAMILY RECEPTORS. They are membrane-bound proteins that are attached to the CELL MEMBRANE either through a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR or through a transmembrane domain. Many of the ephrins are considered important intercellular signaling molecules that control morphogenic changes during embryogenesis.

Common names: Ephrins; Eph Receptor Ligands; Ligands, Eph Receptor; Receptor Ligands, Eph

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Sunday, November 22, 2009

Bidirectional signaling of ErbB and Eph receptors at synapses.

27 Sep 2009 Synapse development and remodeling are regulated by a plethora of molecules such as receptor tyrosine kinases (RTKs), a family of cell surface receptors that play critical roles in neural development. Two families of RTKs implicated in synaptic ... Read more...


Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling.

14 Sep 2009 The cerebral cortex is a laminated sheet of neurons composed of the arrays of intersecting radial columns. During development, excitatory projection neurons originating from the proliferative units at the ventricular surface of the embryonic ... Read more...


Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling.

27 Jul 2009 Extracellular matrixes (ECMs) coat and subdivide animal tissues, but it is unclear how ECM formation is restricted to tissue surfaces and specific cell interfaces. During zebrafish somite morphogenesis, segmental assembly of an ECM composed of ... Read more...

 

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Technical information about 'Ephrins'

Definition: Signaling proteins that are ligands for the EPH FAMILY RECEPTORS. They are membrane-bound proteins that are attached to the CELL MEMBRANE either through a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR or through a transmembrane domain. Many of the ephrins are considered important intercellular signaling molecules that control morphogenic changes during embryogenesis.

Registry Number: 0

Descriptor UI: D036342

Alternative terms: Ephrins; Eph Receptor Ligands; Ligands, Eph Receptor; Receptor Ligands, Eph;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.500; D12.776.467.500; D12.776.543.287; D23.529.500;

History Note: 2003

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