Epilepsy - Drug therapy
Research News and Information

Sunday, November 22, 2009

[Drug-resistant epilepsy]

6 Oct 2009 BACKGROUND: Despite the introduction of many new antiepileptic drugs during recent years, about one third of the epilepsy population continue to have drug-resistant seizures. We present two hypotheses on mechanisms of drug-resistant epileptic ... Read more...

Hughlings Jackson's suggestion for the treatment of epilepsy.

4 Oct 2009 John Hughlings Jackson articulated a neurologic method of systematically evaluating the anatomy, physiology, and pathology of every patient with neurologic disease. He used this mode of analysis to develop a theory of the physiology of epilepsy. We ... Read more...

Prediction of antiepileptic drug efficacy: the use of intracerebral microdialysis to monitor biophase concentrations.

29 Sep 2009 Biophase concentrations of antiepileptic drugs can differ significantly from pharmacokinetics in plasma. A crucial determinant in the disposition of antiepileptic drugs to the brain is represented by the blood-brain barrier. There is growing ... Read more...

Latest indexed articles for 'Epilepsy - Drug therapy'

These are the very latest articles for this heading:

• Martin Brodie: epilepsy expertise and whisky wisdom. 30 Oct 2009
• [Drug-resistant epilepsy] 6 Oct 2009
• Hughlings Jackson's suggestion for the treatment of epilepsy. 4 Oct 2009
• Prediction of antiepileptic drug efficacy: the use of intracerebral microdialysis to monitor biophase concentrations. 29 Sep 2009
• Neurology in the elderly: more trials urgently needed. 29 Sep 2009
• Epilepsy in later life. 29 Sep 2009
• Effect of CYP3A5*3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patients. 29 Sep 2009
• Seizure relapse and development of drug resistance following long-term seizure remission. 29 Sep 2009
• Animal models of focal cortical dysplasia and tuberous sclerosis complex: recent progress toward clinical applications. 29 Sep 2009
• Phenytoin toxicity and thyroid dysfunction. 23 Sep 2009
• Appreciation for study on bromide administration in dogs. 13 Sep 2009
• Antiepileptic drugs in children in developing countries: research and treatment guideline needs. 8 Sep 2009
• The treatment gap of epilepsy in a rural district of Vietnam: a study from the EPIBAVI project. 8 Sep 2009
• What has positron emission tomography told us about the epileptogenic zone? 6 Sep 2009
• Safety and yield of early cessation of AEDs in video-EEG telemetry and outcomes. 30 Aug 2009
• Vagus nerve stimulation. 30 Aug 2009
• Efficacy and tolerability of zonisamide as add-on in brain tumor-related epilepsy: preliminary report. 30 Aug 2009
• Rational polytherapy. 30 Aug 2009
• Refractory seizures: try additional antiepileptic drugs (after two have failed) or go directly to early surgery evaluation? 30 Aug 2009
• Nonphysician management of epilepsy in resource-limited contexts: roles and responsibilities. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Epilepsy'

Definition: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Descriptor UI: D004827

Alternative terms: Epilepsy; Epilepsies; Seizure Disorder; Seizure Disorders; Seizures, Epileptic; Epileptic Seizures; Epileptic Seizure; Seizure, Epileptic; Single Seizure; Seizure, Single; Seizures, Single; Single Seizures; Epilepsy, Cryptogenic; Cryptogenic Epilepsies; Cryptogenic Epilepsy; Epilepsies, Cryptogenic; Aura; Auras; Awakening Epilepsy; Epilepsy, Awakening;

Related Mesh Headings: Seizures;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C10.228.140.490;

Technical Notes: GEN or unspecified; prefer specifics