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Epilepsy - Physiopathology
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Definition of 'Epilepsy'

A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

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Saturday, November 21, 2009

Vagus nerve stimulation for refractory epilepsy in children: More to VNS than seizure frequency reduction.

13 Dec 2009 PURPOSE: Vagus nerve stimulation (VNS) is used increasingly as adjunctive therapy for refractory epilepsy. Studies of VNS in children report mainly seizure frequency reduction as a measure of efficacy and clinical details are often scanty. We report ... Read more...


Sequential processing of lexical, grammatical, and phonological information within Broca's area.

14 Oct 2009 Words, grammar, and phonology are linguistically distinct, yet their neural substrates are difficult to distinguish in macroscopic brain regions. We investigated whether they can be separated in time and space at the circuit level using intracranial ... Read more...


Intracranial EEG reveals a time- and frequency-specific role for the right inferior frontal gyrus and primary motor cortex in stopping initiated responses.

5 Oct 2009 Inappropriate response tendencies may be stopped via a specific fronto/basal ganglia/primary motor cortical network. We sought to characterize the functional role of two regions in this putative stopping network, the right inferior frontal gyrus ... Read more...

 

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Technical information about 'Epilepsy'

Definition: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Descriptor UI: D004827

Alternative terms: Epilepsy; Epilepsies; Seizure Disorder; Seizure Disorders; Seizures, Epileptic; Epileptic Seizures; Epileptic Seizure; Seizure, Epileptic; Single Seizure; Seizure, Single; Seizures, Single; Single Seizures; Epilepsy, Cryptogenic; Cryptogenic Epilepsies; Cryptogenic Epilepsy; Epilepsies, Cryptogenic; Aura; Auras; Awakening Epilepsy; Epilepsy, Awakening;

Related Mesh Headings: Seizures;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C10.228.140.490;

Technical Notes: GEN or unspecified; prefer specifics

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