Epitopes
Research News and Information

Sunday, November 22, 2009

The shared tumor associated antigen cyclin-A2 is recognized by high-avidity T-cells.

13 Nov 2009 Cyclin-A2, a key cell cycle regulator, has been shown to be overexpressed in various types of malignancies with little expression in normal tissue. Such tumor-associated genes potentially are useful targets for cancer immunotherapy. However, ... Read more...

Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity.

2 Nov 2009 The main immunogenic region (MIR) is a conformation-dependent region at the extracellular apex of alpha1 subunits of muscle nicotinic acetylcholine receptor (AChR) that is the target of half or more of the autoantibodies to muscle AChRs in human ... Read more...

Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.

10 Oct 2009 The eye is protected by the ocular immunosurveillance system. We show that tear duct-associated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), ... Read more...

Latest indexed articles for 'Epitopes'

These are the very latest articles for this heading:

• The shared tumor associated antigen cyclin-A2 is recognized by high-avidity T-cells. 13 Nov 2009
• Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity. 2 Nov 2009
• Genetic susceptibility to rheumatoid arthritis: an emerging picture. 13 Oct 2009
• Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. 10 Oct 2009
• CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice. 3 Oct 2009
• Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure. 29 Sep 2009
• Ex vivo expanded telomerase-specific T cells are effective in an orthotopic mouse model for pancreatic adenocarcinoma. 29 Sep 2009
• Conserved leucine residue in the head region of morbillivirus fusion protein regulates the large conformational change during fusion activity. 27 Sep 2009
• Molecular evolution of specific human antibody against MUC1 mucin results in improved recognition of the antigen on tumor cells. 19 Sep 2009
• Undifferentiated nasopharyngeal carcinoma from a nonendemic area: protective role of HLA allele products presenting conserved EBV epitopes. 13 Sep 2009
• Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. 13 Sep 2009
• Beneficial immunomodulation by Streptococcus mutans anti-P1 monoclonal antibodies is Fc independent and correlates with increased exposure of a relevant target epitope. 12 Sep 2009
• New stably transfected bioluminescent cells expressing FLAG epitope-tagged estrogen receptors to study their chromatin recruitment. 7 Sep 2009
• Conformational flexibility and dynamics of two (1-->6)-linked disaccharides related to an oligosaccharide epitope expressed on malignant tumour cells. 5 Sep 2009
• Recruitment of antigen-specific CD8+ T cells in response to infection is markedly efficient. 2 Sep 2009
• Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Sep 2009
• Overlap syndromes: exploring the genetic underpinnings. 30 Aug 2009
• Epitope-tagging Math5 and Pou4f2: new tools to study retinal ganglion cell development in the mouse. 30 Aug 2009
• Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. 30 Aug 2009
• Every shared epitope allele for itself? 30 Aug 2009

See a longer list of these articles.

Technical information about 'Epitopes'

Definition: Sites on an antigen that interact with specific antibodies.

Registry Number: 0

Descriptor UI: D000939

Alternative terms: Epitopes; Antigenic Determinants; Determinants, Antigenic; Antigenic Specificity; Specificity, Antigenic;

Related Mesh Headings: Antibodies, Anti-Idiotypic; Antibody Affinity; Epitope Mapping; Molecular Mimicry;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacology; physiology; poisoning; radiation effects; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D23.050.550;

History Note: 96; was ANTIGENIC DETERMINANTS 1970-95 (as Prov 1970-71)

Technical Notes: X ref ANTIGENIC DETERMINANTS: do not confuse with genetic determinants ( = GENES or specific)