Estradiol - Metabolism
Research News and Information

Sunday, November 22, 2009

Human cytomegalovirus productively infects adrenocortical cells and induces an early cortisol response.

29 Nov 2009 Following our recent findings on the presence of human cytomegalovirus (HCMV) in the normal human adrenal cortex and in adrenocortical tumors, especially in cortisol-secreting tumors, aim of the present study was to investigate the direct effects of ... Read more...

The blood-brain barrier thyroxine transporter organic anion-transporting polypeptide 1c1 displays atypical transport kinetics.

7 Oct 2009 Organic anion-transporting polypeptide (Oatp) 1c1 is a high-affinity T(4) transporter expressed in brain barrier cells. Oatp1c1 transports a variety of additional ligands including the conjugated sterol estradiol 17beta-glucuronide (E(2)17betaG). ... Read more...

Chronic exposure to anabolic androgenic steroids alters neuronal function in the mammalian forebrain via androgen receptor- and estrogen receptor-mediated mechanisms.

5 Oct 2009 Anabolic androgenic steroids (AAS) can promote detrimental effects on social behaviors for which GABA type A (GABA(A)) receptor-mediated circuits in the forebrain play a critical role. While all AAS bind to androgen receptors (AR), they may also be ... Read more...

Latest indexed articles for 'Estradiol - Metabolism'

These are the very latest articles for this heading:

• Human cytomegalovirus productively infects adrenocortical cells and induces an early cortisol response. 29 Nov 2009
• The blood-brain barrier thyroxine transporter organic anion-transporting polypeptide 1c1 displays atypical transport kinetics. 7 Oct 2009
• Chronic exposure to anabolic androgenic steroids alters neuronal function in the mammalian forebrain via androgen receptor- and estrogen receptor-mediated mechanisms. 5 Oct 2009
• Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. 22 Sep 2009
• Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. 21 Sep 2009
• Functional images reflect aggressiveness of endometrial carcinoma: estrogen receptor expression combined with 18F-FDG PET. 14 Sep 2009
• Estrogen biodegradation kinetics and estrogenic activity reduction for two biological wastewater treatment methods. 13 Sep 2009
• Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30. 7 Sep 2009
• 17beta-Estradiol regulates the first steps of skeletal muscle cell differentiation via ER-alpha-mediated signals. 31 Aug 2009
• Estrogen/isoflavone interactions in cynomolgus macaques (Macaca fascicularis). 30 Aug 2009
• Impact of female sex hormones on the maturation and function of human dendritic cells. 30 Aug 2009
• Long-term potentiation in the rat medial vestibular nuclei depends on locally synthesized 17beta-estradiol. 24 Aug 2009
• Neuroanatomical plasticity in the gonadotropin-releasing hormone system of the ewe: seasonal variation in glutamatergic and gamma-aminobutyric acidergic afferents. 18 Aug 2009
• Initial investigation of amenorrhoea. 2 Aug 2009
• Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus. 30 Jul 2009
• Proliferation of estrogen-responsive mouse tumor cell line B-1F stimulated by Saiboku-to, but inhibited by Scutellaria baicalensis, a component of Saiboku-to. 30 Jul 2009
• Perfluorononanoic acid induces apoptosis involving the Fas death receptor signaling pathway in rat testis. 27 Jul 2009
• Indirect regulation of PTH by estrogens may require FGF23. 21 Jul 2009
• NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells. 19 Jul 2009
• 17Beta-estradiol at low concentrations acts through distinct pathways in normal versus benign prostatic hyperplasia-derived prostate stromal cells. 14 Jul 2009

See a longer list of these articles.

Technical information about 'Estradiol'

Definition: Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the PLACENTA. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (RECEPTORS, ESTROGEN) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.

Chemical name: Estra-1,3,5(10)-triene-3,17-diol (17beta)-

Registry Number: 50-28-2

Descriptor UI: D004958

Alternative terms: Estradiol; Estradiol-17 beta; Estradiol 17 beta; Estradiol-17beta; Estradiol 17beta; 17 beta-Oestradiol; 17 beta Oestradiol; Oestradiol; 17 beta-Estradiol; 17 beta Estradiol; Estradiol, (8 alpha,17 beta)-(+-)-Isomer; Estradiol, (9 beta,17 beta)-Isomer; Estradiol, Monosodium Salt; Estradiol, Sodium Salt; Estradiol-17 alpha; Estradiol 17 alpha; Estradiol, (17-alpha)-Isomer; Ovocyclin; Estrace; Estraderm TTS; Estradiol Hemihydrate; Estradiol Hemihydrate, (17 alpha)-Isomer; Estradiol Monohydrate; Estradiol, (+-)-Isomer; Estradiol, (-)-Isomer; Estradiol, (16 alpha,17 alpha)-Isomer; Estradiol, (16 alpha,17 beta)-Isomer; Estradiol, (8 alpha,17 beta)-Isomer; Estradiol, (9 beta,17 alpha)-Isomer;

Related Mesh Headings: Receptors, Estradiol;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Estrogens;

Tree Number: D04.808.365.415.248; D06.472.334.851.437.500;

History Note: 63; for OVOCYCLIN use ESTRADIOL DIPROPIONATE (NM) 1980-98; /therapeutic use was ESTRADIOL, THERAPEUTIC 1965