Estradiol
Research News and Information

Sunday, November 22, 2009

Expression of RIZ1 protein (Retinoblastoma-interacting zinc-finger protein 1) in prostate cancer epithelial cells changes with cancer grade progression and is modulated in vitro by DHT and E2.

29 Nov 2009 The nuclear protein methyl-transferase Retinoblastoma-interacting zinc-finger protein 1 (RIZ1) is considered to be a downstream effector of estrogen action in target tissues. Silencing of RIZ1 expression is common in many tumors. We analyzed RIZ1 ... Read more...

Human cytomegalovirus productively infects adrenocortical cells and induces an early cortisol response.

29 Nov 2009 Following our recent findings on the presence of human cytomegalovirus (HCMV) in the normal human adrenal cortex and in adrenocortical tumors, especially in cortisol-secreting tumors, aim of the present study was to investigate the direct effects of ... Read more...

Attenuation of subarachnoid hemorrhage-induced apoptotic cell death with 17 beta-estradiol. Laboratory investigation.

30 Oct 2009 OBJECT: Apoptosis is implicated in vasospasm and long-term sequelae of subarachnoid hemorrhage (SAH). The authors observed that 17beta-estradiol (E2) can attenuate cerebral vasospasm, lower endothelin-1 production, and preserve normal endothelial ... Read more...

Latest indexed articles for 'Estradiol'

These are the very latest articles for this heading:

• Expression of RIZ1 protein (Retinoblastoma-interacting zinc-finger protein 1) in prostate cancer epithelial cells changes with cancer grade progression and is modulated in vitro by DHT and E2. 29 Nov 2009
• Human cytomegalovirus productively infects adrenocortical cells and induces an early cortisol response. 29 Nov 2009
• Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI study. Nov 2009
• Attenuation of subarachnoid hemorrhage-induced apoptotic cell death with 17 beta-estradiol. Laboratory investigation. 30 Oct 2009
• NAG7 promotes human nasopharyngeal carcinoma invasion through inhibition of estrogen receptor alpha and up-regulation of JNK2/AP-1/MMP1 pathways. 30 Oct 2009
• Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. 12 Oct 2009
• The blood-brain barrier thyroxine transporter organic anion-transporting polypeptide 1c1 displays atypical transport kinetics. 7 Oct 2009
• Comment on "The Arabidopsis circadian clock incorporates a cADPR-based feedback loop". 7 Oct 2009
• Gal4 turnover and transcription activation. 6 Oct 2009
• Chronic exposure to anabolic androgenic steroids alters neuronal function in the mammalian forebrain via androgen receptor- and estrogen receptor-mediated mechanisms. 5 Oct 2009
• Contribution of endogenous opioids to gonadal hormones-induced temporomandibular joint antinociception. 29 Sep 2009
• Acute illness induces the release of aversive odor cues from adult, but not prepubertal, male rats and suppresses social investigation by conspecifics. 29 Sep 2009
• Sex steroids are necessary in the second postnatal week for the expression of male alloparental behavior in prairie voles (Microtus ochragaster). 29 Sep 2009
• [Effects of electroacupuncture on in vitro fertilization-embryo transfer (IVF-ET) of patients with poor ovarian response] 29 Sep 2009
• Properties of estrogen binding components in the plasma membrane of neurohypophysis in hens and changes in its binding before and after oviposition. 29 Sep 2009
• Vitellogenin induction by a mixture of steroidal estrogens in freshwater fishes and relevant risk assessment. 29 Sep 2009
• Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. 22 Sep 2009
• Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. 21 Sep 2009
• Functional images reflect aggressiveness of endometrial carcinoma: estrogen receptor expression combined with 18F-FDG PET. 14 Sep 2009
• Estrogen biodegradation kinetics and estrogenic activity reduction for two biological wastewater treatment methods. 13 Sep 2009

See a longer list of these articles.

Technical information about 'Estradiol'

Definition: Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the PLACENTA. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (RECEPTORS, ESTROGEN) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.

Chemical name: Estra-1,3,5(10)-triene-3,17-diol (17beta)-

Registry Number: 50-28-2

Descriptor UI: D004958

Alternative terms: Estradiol; Estradiol-17 beta; Estradiol 17 beta; Estradiol-17beta; Estradiol 17beta; 17 beta-Oestradiol; 17 beta Oestradiol; Oestradiol; 17 beta-Estradiol; 17 beta Estradiol; Estradiol, (8 alpha,17 beta)-(+-)-Isomer; Estradiol, (9 beta,17 beta)-Isomer; Estradiol, Monosodium Salt; Estradiol, Sodium Salt; Estradiol-17 alpha; Estradiol 17 alpha; Estradiol, (17-alpha)-Isomer; Ovocyclin; Estrace; Estraderm TTS; Estradiol Hemihydrate; Estradiol Hemihydrate, (17 alpha)-Isomer; Estradiol Monohydrate; Estradiol, (+-)-Isomer; Estradiol, (-)-Isomer; Estradiol, (16 alpha,17 alpha)-Isomer; Estradiol, (16 alpha,17 beta)-Isomer; Estradiol, (8 alpha,17 beta)-Isomer; Estradiol, (9 beta,17 alpha)-Isomer;

Related Mesh Headings: Receptors, Estradiol;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Estrogens;

Tree Number: D04.808.365.415.248; D06.472.334.851.437.500;

History Note: 63; for OVOCYCLIN use ESTRADIOL DIPROPIONATE (NM) 1980-98; /therapeutic use was ESTRADIOL, THERAPEUTIC 1965