Excitatory Amino Acid Agonists - Pharmacology
Research News and Information

Tuesday, November 24, 2009

Kv7/KCNQ channels control action potential phasing of pyramidal neurons during hippocampal gamma oscillations in vitro.

19 Oct 2009 While the synaptic mechanisms involved in the generation of in vitro network oscillations have been widely studied, little is known about the importance of voltage-gated currents during such activity. Here we study the role of the M-current (I(M)) ... Read more...

Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking.

12 Oct 2009 The postsynaptic density (PSD) consists of a lattice-like array of interacting proteins that organizes and stabilizes receptors, ion channels, structural, and signaling proteins necessary for synaptic function. To study the stabilization of proteins ... Read more...

Increase of intracellular Ca2+ by P2Y but not P2X receptors in cultured cortical multipolar neurons of the rat.

8 Oct 2009 The expression and functionality of P2X/P2Y receptor subtypes in multipolar nonpyramidal neurons of mixed cortical cell cultures were investigated by means of immunocytochemistry and fura-2 microfluorimetry. The morphological studies revealed that ... Read more...

Latest indexed articles for 'Excitatory Amino Acid Agonists - Pharmacology'

These are the very latest articles for this heading:

• Kv7/KCNQ channels control action potential phasing of pyramidal neurons during hippocampal gamma oscillations in vitro. 19 Oct 2009
• Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking. 12 Oct 2009
• Increase of intracellular Ca2+ by P2Y but not P2X receptors in cultured cortical multipolar neurons of the rat. 8 Oct 2009
• Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2(High) receptor. 29 Sep 2009
• Group I mGluR activation enhances Ca(2+)-dependent nonselective cation currents and rhythmic bursting in main olfactory bulb external tufted cells. 21 Sep 2009
• AMPA receptor ligand binding domain mobility revealed by functional cross linking. 21 Sep 2009
• Basal forebrain lactate release and promotion of cortical arousal during prolonged waking is attenuated in aging. 14 Sep 2009
• Selective expression of ligand-gated ion channels in L5 pyramidal cell axons. 14 Sep 2009
• Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling. 7 Sep 2009
• Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell death. 2 Sep 2009
• Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons. 25 Aug 2009
• Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis? 24 Aug 2009
• Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activation. 11 Aug 2009
• The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization. 11 Aug 2009
• High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retina. 7 Aug 2009
• Glutamate agonists for treating schizophrenia have affinity for dopamine D2High and D3 receptors. 30 Jul 2009
• Agonist-induced internalization of mGluR1alpha is mediated by caveolin. 15 Jul 2009
• Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum. 15 Jul 2009
• GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. 14 Jul 2009
• Guanosine-5'-monophosphate induces cell death in rat hippocampal slices via ionotropic glutamate receptors activation and glutamate uptake inhibition. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Excitatory Amino Acid Agonists'

Definition: Drugs that bind to and activate excitatory amino acid receptors.

Registry Number: 0

Descriptor UI: D018690

Alternative terms: Excitatory Amino Acid Agonists; Amino Acid Agonist, Excitatory; Amino Acid Agonists, Excitatory; EAA Agonists; Agonists, EAA; Amino Acids, Excitatory, Agonists; EAA Agonist; Agonist, EAA; Agonists, Excitatory Amino Acid; Excitatory Amino Acid Agonist; Glutamate Agonists; Agonists, Glutamate; Glutamate Agonist; Agonist, Glutamate;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.625.190.200; D27.505.696.577.190.200;

History Note: 95

Technical Notes: note X ref GLUTAMATE AGONISTS: do not coord with GLUTAMATES; GEN or unspecified; prefer specifics; DF: EAA AG