Excitatory Amino Acid Agonists - Toxicity
Research News and Information

Saturday, November 21, 2009

Evaluation of N-benzyl-N-[11C]methyl-2- (7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC) as a novel translocator protein (18 kDa) radioligand in kainic acid-lesioned rat.

30 Oct 2009 The aim of this study was to evaluate N-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC) as a new translocator protein (18 kDa) [TSPO, formerly known as the peripheral-type benzodiazepine receptor (PBR)] ... Read more...

Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.

29 Sep 2009 Glutamate receptor-mediated excitotoxicity and mitochondrial dysfunction appear to play an important role in motoneuron (MN) degeneration in amyotrophic lateral sclerosis (ALS). In the present study we used an organotypic slice culture of chick ... Read more...

Glutamate agonist causes irreversible degeneration of inner hair cells.

21 Sep 2009 Glutamate neurotoxicity in cochlear hair cells was investigated by administering the glutamate agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) into the scala tympani of Mongolian gerbils. AMPA administration caused the formation ... Read more...

Latest indexed articles for 'Excitatory Amino Acid Agonists - Toxicity'

These are the very latest articles for this heading:

• Evaluation of N-benzyl-N-[11C]methyl-2- (7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC) as a novel translocator protein (18 kDa) radioligand in kainic acid-lesioned rat. 30 Oct 2009
• Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord. 29 Sep 2009
• Glutamate agonist causes irreversible degeneration of inner hair cells. 21 Sep 2009
• Beta-amyloid monomers are neuroprotective. 24 Aug 2009
• Excitotoxicity-associated p53 expression in adult rat retina is mediated by calpain activity but not by Cl- influx. 30 Jul 2009
• Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine. 13 Jul 2009
• Transthyretin knockout mice display decreased susceptibility to AMPA-induced neurodegeneration. 8 Jul 2009
• Hippocampal injury, atrophy, synaptic reorganization, and epileptogenesis after perforant pathway stimulation-induced status epilepticus in the mouse. 8 Jul 2009
• Alterations in excitotoxicity and prostaglandin metabolism in a transgenic mouse model of Alzheimer's disease. 24 Jun 2009
• Making context memories independent of the hippocampus. 22 Jun 2009
• Evidence of action sequence chunking in goal-directed instrumental conditioning and its dependence on the dorsomedial prefrontal cortex. 22 Jun 2009
• FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. 22 Jun 2009
• The formation of recent and remote memory is associated with time-dependent formation of dendritic spines in the hippocampus and anterior cingulate cortex. 22 Jun 2009
• A cholinergic-dependent role for the entorhinal cortex in trace fear conditioning. 22 Jun 2009
• Lactation is a natural model of hippocampus neuroprotection against excitotoxicity. 15 Jun 2009
• Functional differentiation and cooperation among the hippocampal subregions in rats to effect spatial memory processes. 6 Jun 2009
• A discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response. Jun 2009
• Activin A is essential for neurogenesis following neurodegeneration. 30 May 2009
• Effects of a single postnatal methamphetamine administration on NMDA-induced seizures are sex- and prenatal exposure-specific. 12 May 2009
• Decreased nitric oxide markers and morphological changes in the brain of arsenic-exposed rats. May 2009

See a longer list of these articles.

Technical information about 'Excitatory Amino Acid Agonists'

Definition: Drugs that bind to and activate excitatory amino acid receptors.

Registry Number: 0

Descriptor UI: D018690

Alternative terms: Excitatory Amino Acid Agonists; Amino Acid Agonist, Excitatory; Amino Acid Agonists, Excitatory; EAA Agonists; Agonists, EAA; Amino Acids, Excitatory, Agonists; EAA Agonist; Agonist, EAA; Agonists, Excitatory Amino Acid; Excitatory Amino Acid Agonist; Glutamate Agonists; Agonists, Glutamate; Glutamate Agonist; Agonist, Glutamate;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.625.190.200; D27.505.696.577.190.200;

History Note: 95

Technical Notes: note X ref GLUTAMATE AGONISTS: do not coord with GLUTAMATES; GEN or unspecified; prefer specifics; DF: EAA AG