Excitatory Amino Acid Antagonists - Pharmacology
Research News and Information

Sunday, November 22, 2009

Metaplasticity governs natural experience-driven plasticity of nascent embryonic brain circuits.

27 Oct 2009 During embryogenesis, brain neurons receiving the same sensory input may undergo potentiation or depression. While the origin of variable plasticity in vivo is unknown, it plays a key role in shaping dynamic neural circuit refinement. Here, we ... Read more...

Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord.

19 Oct 2009 Pure NMDA receptor (NMDAr)-mediated EPSCs, thought to correspond to "silent" glutamatergic synapses that lack AMPA receptors (AMPArs), have been observed in superficial spinal dorsal horn of neonatal but not adult rats. Recent anatomical studies ... Read more...

The time course of dopamine transmission in the ventral tegmental area.

19 Oct 2009 Synaptic transmission mediated by G-protein coupled receptors (GPCR) is not generally thought to be point-to-point. To determine the extent over which dopamine signals in the midbrain, the present study examined the concentration and time course of ... Read more...

Latest indexed articles for 'Excitatory Amino Acid Antagonists - Pharmacology'

These are the very latest articles for this heading:

• Metaplasticity governs natural experience-driven plasticity of nascent embryonic brain circuits. 27 Oct 2009
• Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord. 19 Oct 2009
• The time course of dopamine transmission in the ventral tegmental area. 19 Oct 2009
• Nitric oxide potentiation of locomotor activity in the spinal cord of the lamprey. 19 Oct 2009
• Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling. 19 Oct 2009
• Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. 12 Oct 2009
• Factors governing single-trial contextual fear conditioning in the weanling rat. 29 Sep 2009
• N-type calcium channels mediate a GABA(B) presynaptic modulation in the corticostriatal synapse in turtle's paleostriatum augmentatum. 29 Sep 2009
• Dynamics of fast and slow inhibition from cerebellar golgi cells allow flexible control of synaptic integration. 22 Sep 2009
• AMPA receptor ligand binding domain mobility revealed by functional cross linking. 21 Sep 2009
• GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses. 14 Sep 2009
• Negative shift in the glycine reversal potential mediated by a Ca2+- and pH-dependent mechanism in interneurons. 14 Sep 2009
• Selective expression of ligand-gated ion channels in L5 pyramidal cell axons. 14 Sep 2009
• CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity. 5 Sep 2009
• The timing of external input controls the sign of plasticity at local synapses. 4 Sep 2009
• Approach sensitivity in the retina processed by a multifunctional neural circuit. 4 Sep 2009
• Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. 4 Sep 2009
• Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy. 29 Aug 2009
• Older and stronger object memories are selectively destabilized by reactivation in the presence of new information. 25 Aug 2009
• Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons. 25 Aug 2009

See a longer list of these articles.

Technical information about 'Excitatory Amino Acid Antagonists'

Definition: Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.

Registry Number: 0

Descriptor UI: D018691

Alternative terms: Excitatory Amino Acid Antagonists; Antagonists, Excitatory Amino Acid; Amino Acids, Excitatory, Antagonists; Glutamate Receptor Antagonists; Antagonists, Glutamate Receptor; Receptor Antagonists, Glutamate; EAA Antagonists; Antagonists, EAA; Glutamate Antagonists; Antagonists, Glutamate; Amino Acid Antagonists, Excitatory;

Allowable Qualifiers: isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology;

Tree Number: D27.505.519.625.190.300; D27.505.696.577.190.300;

History Note: 95

Technical Notes: GEN or unspecified; prefer specifics; DF: EAA ANTAG