Exploratory Behavior - Drug effects
Research News and Information

Saturday, November 21, 2009

Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation.

30 Oct 2009 We tested the hypothesis that increased dopaminergic sensitivity induced by olfactory bulbectomy is mediated by dysregulation of endocannabinoid signaling. Bilateral olfactory bulbectomy induces behavioral and neurobiological symptomatology related ... Read more...

MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning.

29 Sep 2009 3,4-Methylenedioxymethamphetamine (MDMA) is a drug of abuse worldwide and a selective serotonin (5-HT) neurotoxin. An important factor in the risk of drug abuse and relapse is stress. Although multiple parallels exist between MDMA abuse and stress, ... Read more...

Double dissociation and hierarchical organization of strategy switches and reversals in the rat PFC.

29 Sep 2009 Prelimbic-infralimbic cortex (PL-IL) and orbitofrontal cortex (OFC) influence behavioral flexibility in the rat. The authors tested the effects of PL-IL or OFC infusion with the GABA agonist muscimol in the context of 2 flexible responding tasks: ... Read more...

Latest indexed articles for 'Exploratory Behavior - Drug effects'

These are the very latest articles for this heading:

• Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation. 30 Oct 2009
• MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning. 29 Sep 2009
• Double dissociation and hierarchical organization of strategy switches and reversals in the rat PFC. 29 Sep 2009
• Effects of some 1,3,5-trisubstitued-2-pyrazoline derivatives on depression and anxiety parameters of mice. 24 Sep 2009
• NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory. 8 Sep 2009
• Hyperactivity induced by antiphospholipid syndrome serum. 30 Aug 2009
• Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice. 25 Aug 2009
• Older and stronger object memories are selectively destabilized by reactivation in the presence of new information. 25 Aug 2009
• Erythropoietin sustains cognitive function and brain volume after neonatal stroke. 9 Aug 2009
• Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia. 25 Jul 2009
• Marked behavioral activation from inhibitory stimulation of locus coeruleus alpha1-adrenoceptors by a full agonist. 22 Jul 2009
• Testosterone and dihydrotestosterone differentially improve cognition in aged female mice. 22 Jul 2009
• PolyADP-ribosylation is required for long-term memory formation in mammals. 21 Jul 2009
• Antidepressant properties of the 5-HT4 receptor partial agonist, SL65.0155: behavioral and neurochemical studies in rats. 17 Jul 2009
• Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model. 16 Jul 2009
• Novel environment and GABA agonists alter event-related potentials in N-methyl-D-aspartate NR1 hypomorphic and wild-type mice. 12 Jul 2009
• Combinational chelation therapy abrogates lead-induced neurodegeneration in rats. 8 Jul 2009
• Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring. 6 Jul 2009
• Prefrontal cortex and spinal cord mediated anti-neuropathy and analgesia induced by sarcosine, a glycine-T1 transporter inhibitor. Jul 2009
• Individual differences in response to novelty and the conditioned locomotor effects of nicotine. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Exploratory Behavior'

Definition: The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity.

Descriptor UI: D005106

Alternative terms: Exploratory Behavior; Behavior, Exploratory; Behaviors, Exploratory; Exploratory Behaviors; Curiosity; Curiosities; Novelty-Seeking Behavior; Behavior, Novelty-Seeking; Behaviors, Novelty-Seeking; Novelty Seeking Behavior; Novelty-Seeking Behaviors;

Allowable Qualifiers: classification; drug effects; physiology; radiation effects; ethics;

Tree Number: F01.145.387; F01.658.370;

Online Note: use EXPLORATORY BEHAVIOR to search BEHAVIOR, EXPLORATORY 1966-67 & CURIOSITY 1969-78

History Note: 68; was BEHAVIOR, EXPLORATORY 1965-67; CURIOSITY was see under EXPLORATORY BEHAVIOR 1969-78

Technical Notes: human & animal