Extracellular Signal-Regulated MAP Kinases - Antagonists & inhibitors
Research News and Information

Sunday, November 22, 2009

W7FW14F apomyoglobin amyloid aggregates-mediated apoptosis is due to oxidative stress and AKT inactivation caused by Ras and Rac.

30 Oct 2009 We have previously reported that addition of prefibrillar aggregates (PFAs) derived from W7FW14F apomyoglobin mutant to NIH-3T3 cells affects their viability. In this article, we have found that cytotoxicity induced by PFAs in NIH 3T3 and SH-SY5Y ... Read more...

Sevoflurane preconditioning induces rapid ischemic tolerance against spinal cord ischemia/reperfusion through activation of extracellular signal-regulated kinase in rabbits.

29 Sep 2009 BACKGROUND: The protective effect of sevoflurane preconditioning against spinal cord ischemia/reperfusion (I/R) is unclear. We designed this study to investigate whether sevoflurane preconditioning could induce rapid ischemic tolerance to the spinal ... Read more...

Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways.

29 Sep 2009 Osteosarcoma is characterized by a high malignant and metastatic potential. The chemokine stromal-derived factor-1alpha (SDF-1alpha) and its receptor, CXCR4, play a crucial role in adhesion and migration of human cancer cells. Integrins are the ... Read more...

Latest indexed articles for 'Extracellular Signal-Regulated MAP Kinases - Antagonists & inhibitors'

These are the very latest articles for this heading:

• W7FW14F apomyoglobin amyloid aggregates-mediated apoptosis is due to oxidative stress and AKT inactivation caused by Ras and Rac. 30 Oct 2009
• Sevoflurane preconditioning induces rapid ischemic tolerance against spinal cord ischemia/reperfusion through activation of extracellular signal-regulated kinase in rabbits. 29 Sep 2009
• Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. 29 Sep 2009
• Beyond thermodynamics: drug binding kinetics could influence epidermal growth factor signaling. 22 Sep 2009
• Involvement of polyadenylation status on maternal gene expression during in vitro maturation of porcine oocytes. 30 Aug 2009
• Early zygotic expression of transcription factors and signal molecules in fully dissociated embryonic cells of Ciona intestinalis: A microarray analysis. 30 Aug 2009
• Essential involvement of cross-talk between IFN-gamma and TNF-alpha in CXCL10 production in human THP-1 monocytes. 30 Aug 2009
• Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. 24 Aug 2009
• Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. 13 Aug 2009
• Spots and stripes: pleomorphic patterning of stem cells via p-ERK-dependent cell chemotaxis shown by feather morphogenesis and mathematical simulation. 4 Aug 2009
• Differential inhibition of single and cluster type tumor cell migration. 30 Jul 2009
• Interactions between mitogen-activated protein kinase and protein kinase C signaling during oocyte maturation and fertilization in a marine worm. 30 Jul 2009
• GM-CSF regulates fusion of mononuclear osteoclasts into bone-resorbing osteoclasts by activating the Ras/ERK pathway. 27 Jul 2009
• Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling. 26 Jul 2009
• Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3. 22 Jul 2009
• Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthma. 15 Jul 2009
• Dimethylfumarate inhibits tumor cell invasion and metastasis by suppressing the expression and activities of matrix metalloproteinases in melanoma cells. 8 Jul 2009
• Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cells. 7 Jul 2009
• Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide. 5 Jul 2009
• P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestine. 4 Jul 2009

See a longer list of these articles.

Technical information about 'Extracellular Signal-Regulated MAP Kinases'

Definition: A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.

Registry Number: EC 2.7.1.37

Descriptor UI: D048049

Alternative terms: Extracellular Signal-Regulated MAP Kinases; Extracellular Signal Regulated MAP Kinases; MAP Kinases, Extracellular Signal-Regulated; MAP Kinases, Extracellular Signal Regulated; ERK MAP Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal Regulated Kinases; Kinases, Extracellular Signal-Regulated;

Allowable Qualifiers: ultrastructure; urine; chemistry; contraindications; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity;

Tree Number: D08.811.913.696.620.682.700.567.342; D08.811.913.696.620.682.700.646.750.249; D12.644.360.450.169; D12.776.476.450.169;

History Note: 2005; for EXTRACELLULAR SIGNAL-REGULATED KINASES use MITOGEN-ACTIVATED PROTEIN KINASES 1994-2004

Technical Notes: note specifics