Extracellular Signal-Regulated MAP Kinases - Physiology
Research News and Information

Sunday, November 22, 2009

Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation.

27 Sep 2009 Cell death by the process of apoptosis plays important roles in development, tissue homeostasis, diseases and drug responses. The cysteine aspartyl protease caspase-9 plays a central role in the mitochondrial or intrinsic apoptotic pathway that is ... Read more...

Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -'trick or treats'?

27 Sep 2009 Macroautophagy (hereafter referred to as autophagy) is a tightly regulated lysosome-dependent catabolic pathway. During this process, cytosolic constituents are sequestered into autophagosomes, which subsequently fuse with lysosomes to become ... Read more...

A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis.

19 Sep 2009 The C-type lectin dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) mediates the innate immune recognition of microbial carbohydrates. We investigated the function of this molecule in the host response to ... Read more...

Latest indexed articles for 'Extracellular Signal-Regulated MAP Kinases - Physiology'

These are the very latest articles for this heading:

• Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation. 27 Sep 2009
• Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -'trick or treats'? 27 Sep 2009
• A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. 19 Sep 2009
• Protective effect of sulforaphane on indomethacin-induced cytotoxicity via heme oxygenase-1 expression in human intestinal Int 407 cells. 30 Aug 2009
• Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells. 18 Aug 2009
• Disturbed mitotic progression and genome segregation are involved in cell transformation mediated by nano-TiO2 long-term exposure. 16 Aug 2009
• Phosphorylation of Nur77 by the MEK-ERK-RSK cascade induces mitochondrial translocation and apoptosis in T cells. 10 Aug 2009
• Spots and stripes: pleomorphic patterning of stem cells via p-ERK-dependent cell chemotaxis shown by feather morphogenesis and mathematical simulation. 4 Aug 2009
• B7-H1 expression is regulated by MEK/ERK signaling pathway in anaplastic large cell lymphoma and Hodgkin lymphoma. 30 Jul 2009
• Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling. 30 Jul 2009
• GM-CSF regulates fusion of mononuclear osteoclasts into bone-resorbing osteoclasts by activating the Ras/ERK pathway. 27 Jul 2009
• Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells. 26 Jul 2009
• Curcumin reduced the side effects of mitomycin C by inhibiting GRP58-mediated DNA cross-linking in MCF-7 breast cancer xenografts. 21 Jul 2009
• Thrombin induces EGF receptor expression and cell proliferation via a PKC(delta)/c-Src-dependent pathway in vascular smooth muscle cells. 21 Jul 2009
• Impaired recovery of blood flow after hind-limb ischemia in mice lacking guanylyl cyclase-A, a receptor for atrial and brain natriuretic peptides. 21 Jul 2009
• Activation of latent transforming growth factor-beta1 by nitric oxide in macrophages: role of soluble guanylate cyclase and MAP kinases. 29 Jun 2009
• MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation. 29 Jun 2009
• Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease. 29 Jun 2009
• Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. 29 Jun 2009
• Deletion of LOX-1 attenuates renal injury following angiotensin II infusion. 22 Jun 2009

See a longer list of these articles.

Technical information about 'Extracellular Signal-Regulated MAP Kinases'

Definition: A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.

Registry Number: EC 2.7.1.37

Descriptor UI: D048049

Alternative terms: Extracellular Signal-Regulated MAP Kinases; Extracellular Signal Regulated MAP Kinases; MAP Kinases, Extracellular Signal-Regulated; MAP Kinases, Extracellular Signal Regulated; ERK MAP Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal Regulated Kinases; Kinases, Extracellular Signal-Regulated;

Allowable Qualifiers: ultrastructure; urine; chemistry; contraindications; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity;

Tree Number: D08.811.913.696.620.682.700.567.342; D08.811.913.696.620.682.700.646.750.249; D12.644.360.450.169; D12.776.476.450.169;

History Note: 2005; for EXTRACELLULAR SIGNAL-REGULATED KINASES use MITOGEN-ACTIVATED PROTEIN KINASES 1994-2004

Technical Notes: note specifics