Extracellular Signal-Regulated MAP Kinases
Research News and Information

Saturday, November 21, 2009

Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling.

29 Nov 2009 The role of OxLDL in the generation and progression of atherosclerosis is well admitted. In addition, it is well known that atherosclerosis is often accompanied by perturbations in bone remodeling, resulting in osteoporosis. In the current studies, ... Read more...

Rapamycin impairs trabecular bone acquisition from high-dose but not low-dose intermittent parathyroid hormone treatment.

29 Nov 2009 The osteo-anabolic effects of intermittent parathyroid hormone (PTH) treatment require insulin-like growth factor (IGF) signaling through the IGF-I receptor. A major downstream target of the IGF-I receptor (via Akt) is the mammalian target of ... Read more...

Prostaglandin E(2) promotes cell proliferation via protein kinase C/extracellular signal regulated kinase pathway-dependent induction of c-Myc expression in human esophageal squamous cell carcinoma cells.

29 Nov 2009 Overexpression of cyclooxygenase-2 (COX-2) and elevation of its derivative prostaglandin E(2) (PGE(2)) are implicated in human esophageal squamous cell carcinoma. The expression of c-Myc, an oncogenic transcription factor, is also upregulated in ... Read more...

Latest indexed articles for 'Extracellular Signal-Regulated MAP Kinases'

These are the very latest articles for this heading:

• Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling. 29 Nov 2009
• Rapamycin impairs trabecular bone acquisition from high-dose but not low-dose intermittent parathyroid hormone treatment. 29 Nov 2009
• Prostaglandin E(2) promotes cell proliferation via protein kinase C/extracellular signal regulated kinase pathway-dependent induction of c-Myc expression in human esophageal squamous cell carcinoma cells. 29 Nov 2009
• Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival. 30 Oct 2009
• The IL-8 production by Streptococcal pyrogenic exotoxin B. 30 Oct 2009
• Radiosensitization effect of STI-571 on pancreatic cancer cells in vitro. 30 Oct 2009
• W7FW14F apomyoglobin amyloid aggregates-mediated apoptosis is due to oxidative stress and AKT inactivation caused by Ras and Rac. 30 Oct 2009
• The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse. 14 Oct 2009
• Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. 14 Oct 2009
• Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis. 29 Sep 2009
• PORE-ing over ERK substrates. 29 Sep 2009
• T cell receptor signaling induced by an analog peptide of type II collagen requires activation of Syk. 29 Sep 2009
• Licking decreases phosphorylation of extracellular signal-regulated kinase in the dorsal horn of the spinal cord after a formalin test. 29 Sep 2009
• Sevoflurane preconditioning induces rapid ischemic tolerance against spinal cord ischemia/reperfusion through activation of extracellular signal-regulated kinase in rabbits. 29 Sep 2009
• Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. 29 Sep 2009
• Osteopontin increases migration and MMP-9 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells. 29 Sep 2009
• Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics. 27 Sep 2009
• Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation. 27 Sep 2009
• Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -'trick or treats'? 27 Sep 2009
• SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc(epsilon)RI-induced activation of Fyn and Erk pathways leading to TNF(alpha) release from bone marrow-derived mast cells. 26 Sep 2009

See a longer list of these articles.

Technical information about 'Extracellular Signal-Regulated MAP Kinases'

Definition: A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.

Registry Number: EC 2.7.1.37

Descriptor UI: D048049

Alternative terms: Extracellular Signal-Regulated MAP Kinases; Extracellular Signal Regulated MAP Kinases; MAP Kinases, Extracellular Signal-Regulated; MAP Kinases, Extracellular Signal Regulated; ERK MAP Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal Regulated Kinases; Kinases, Extracellular Signal-Regulated;

Allowable Qualifiers: ultrastructure; urine; chemistry; contraindications; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity;

Tree Number: D08.811.913.696.620.682.700.567.342; D08.811.913.696.620.682.700.646.750.249; D12.644.360.450.169; D12.776.476.450.169;

History Note: 2005; for EXTRACELLULAR SIGNAL-REGULATED KINASES use MITOGEN-ACTIVATED PROTEIN KINASES 1994-2004

Technical Notes: note specifics