Factor VIII - History
Research News and Information

Monday, November 23, 2009

Quantifying the source of infection for HIV-infected hemophiliacs in the U.K. from 1979 to 1984.

29 Apr 2009 There is considerable literature on the risk of HIV infection for individuals suffering from hemophilia A in the United Kingdom (U.K.) during the period 1979-1984 when the sources of Factor VIII clotting factor were contaminated with HIV. Toward the ... Read more...

Haemate P von Willebrand factor/factor VIII concentrate: 25 years of clinical experience.

30 Oct 2008 Although von Willebrand disease (VWD) has a very long history, our understanding and treatment of the bleeding disorder has only evolved during the past 50 years or so. It was not until the 1920s that VWD was first recognized as a disease separate ... Read more...

Firm behavior in the U.S. market for factor VIII: a need for policy?

29 Nov 1994 In this paper, we historically examine the market for Factor VIII concentrate, a collection of blood products used in the treatment of hemophilia A. With the introduction of HIV-1 into the U.S. blood supply, a majority of American hemophiliacs ... Read more...

Latest indexed articles for 'Factor VIII - History'

These are the very latest articles for this heading:

• Quantifying the source of infection for HIV-infected hemophiliacs in the U.K. from 1979 to 1984. 29 Apr 2009
• Haemate P von Willebrand factor/factor VIII concentrate: 25 years of clinical experience. 30 Oct 2008
• Remembrances of factor VIII. Part 2: the path to mutation discovery. 30 May 2006
• Unraveling the mystery of von Willebrand factor. 27 Feb 2006
• Big piece, little piece or: yes, factor VIII is a protein. 30 Aug 2005
• Remembrances of factor VIII. Part 1: the race to the gene. 28 Feb 2004
• Desmopressin (DDAVP) and factor VIII. 30 Aug 2003
• Desmopressin (DDAVP) and factor VIII: the tale as viewed from Milan (and Malmö). 30 Mar 2003
• DDAVP and factor VIII: a tale from Edinburgh. 30 Mar 2003
• In search of the eighth factor: a personal reminiscence. 27 Feb 2003
• On the way to virus-safe blood coagulation factor concentrates. 30 Mar 2002
• Firm behavior in the U.S. market for factor VIII: a need for policy? 29 Nov 1994
• The need for recombinant factor VIII: historical background and rationale. 30 Mar 1991
• The clinical use of porcine factor VIII. 30 Dec 1989
• Abstracts of a symposium on "Factor VIII/von Willebrand Factor, Platelet Formation, and Function in Health and Disease: A Tribute to Dr. Marion I. Barnhart". Detroit, Michigan, November 21 and 22, 1986. 30 Mar 1987
• The history of haemophilia. 30 May 1976
• Remembrance of former things. 29 Jun 1972

See a longer list of these articles.

Technical information about 'Factor VIII'

Definition: Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.

Chemical name: Blood-coagulation factor VIII, complex

Registry Number: 9001-27-8

Descriptor UI: D005169

Alternative terms: Factor VIII; Thromboplastinogen; Coagulation Factor VIII; Factor VIII, Coagulation; VIII, Coagulation Factor; Antihemophilic Factor; Blood Coagulation Factor VIII; Factor VIII Procoagulant Activity; Factor VIII-Heavy Chain; Factor VIII Heavy Chain; Factor VIIIC; F VIII-C; F VIII C; Humate-P; Humate P; HumateP; Hyatt-C; Hyatt C; HyattC; Hyate-C; Hyate C; HyateC; Monoclate; Factor VIII Coagulant Antigen; Factor VIII Clotting Antigen; Hemofil; Hemofil M; Hemophil; Hemofil HM;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Pharmacological Action: Coagulants;

Tree Number: D12.776.124.125.350; D23.119.350;