Factor VIII
Research News and Information

Monday, November 23, 2009

Structural organization of Weibel-Palade bodies revealed by cryo-EM of vitrified endothelial cells.

27 Sep 2009 In endothelial cells, the multifunctional blood glycoprotein von Willebrand Factor (VWF) is stored for rapid exocytic release in specialized secretory granules called Weibel-Palade bodies (WPBs). Electron cryomicroscopy at the thin periphery of ... Read more...

Adsorption and function of recombinant Factor VIII at the air-water interface in the presence of Tween 80.

30 Aug 2009 The air-water surface tension kinetic and steady state behavior exhibited by a recombinant Factor VIII were recorded in the presence of the surfactant Tween 80. The rate of surface tension decrease was determined to be greater for rFVIII-Tween ... Read more...

A review of ERGIC-53: its structure, functions, regulation and relations with diseases.

30 Aug 2009 ERGIC-53 is a type I transmembrane protein. It includes an N-terminal signal sequence, a carbohydrate recognition domain, which is calcium-dependent and pH-sensitive, a stalk region, a transmembrane domain, and a short cytoplasmic domain; ERGIC-53 ... Read more...

Latest indexed articles for 'Factor VIII'

These are the very latest articles for this heading:

• Clinical problem-solving. A bloody mystery. 3 Nov 2009
• Acquired factor VIII inhibitor. 30 Oct 2009
• Structural organization of Weibel-Palade bodies revealed by cryo-EM of vitrified endothelial cells. 27 Sep 2009
• [89-year-old woman with hemorrhagic diathesis] 14 Sep 2009
• Adsorption and function of recombinant Factor VIII at the air-water interface in the presence of Tween 80. 30 Aug 2009
• A review of ERGIC-53: its structure, functions, regulation and relations with diseases. 30 Aug 2009
• Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma. 30 Aug 2009
• Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity. 15 Aug 2009
• Inflammation and thrombosis biomarkers and incident frailty in postmenopausal women. 11 Aug 2009
• Enhanced efficacy of recombinant FVIII in noncovalent complex with PEGylated liposome in hemophilia A mice. 2 Aug 2009
• Multimerization of peptide mimotopes for blocking of factor VIII neutralizing antibodies. 30 Jul 2009
• Stroke in sickle cell anemia: alternative etiologies. 30 Jul 2009
• Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. 30 Jul 2009
• Novel human pathological mutations. Gene symbol: F8. Disease: Hemophilia A. 30 Jul 2009
• Novel human pathological mutations. Gene symbol: F8. Disease: Haemophilia A. 30 Jul 2009
• Furtive bleeding. 30 Jul 2009
• Inhibitors of factor VIII in hemophilia. 14 Jul 2009
• Inhibitors of factor VIII in hemophilia. 14 Jul 2009
• Inhibitors of factor VIII in hemophilia. 14 Jul 2009
• Inhibitors of factor VIII in hemophilia. 14 Jul 2009

See a longer list of these articles.

Technical information about 'Factor VIII'

Definition: Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.

Chemical name: Blood-coagulation factor VIII, complex

Registry Number: 9001-27-8

Descriptor UI: D005169

Alternative terms: Factor VIII; Thromboplastinogen; Coagulation Factor VIII; Factor VIII, Coagulation; VIII, Coagulation Factor; Antihemophilic Factor; Blood Coagulation Factor VIII; Factor VIII Procoagulant Activity; Factor VIII-Heavy Chain; Factor VIII Heavy Chain; Factor VIIIC; F VIII-C; F VIII C; Humate-P; Humate P; HumateP; Hyatt-C; Hyatt C; HyattC; Hyate-C; Hyate C; HyateC; Monoclate; Factor VIII Coagulant Antigen; Factor VIII Clotting Antigen; Hemofil; Hemofil M; Hemophil; Hemofil HM;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Pharmacological Action: Coagulants;

Tree Number: D12.776.124.125.350; D23.119.350;