Fibroblast Growth Factor 2 - Physiology
Research News and Information

Sunday, November 22, 2009

Suppression of fibroblast growth factor-2 expression: possible mechanism underlying methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells.

29 Sep 2009 Vascular toxicity is an important feature of the neuropathy induced by methylmercury. Methylmercury does not cause nonspecific cell damage, but rather retards the repair of wounded monolayers of cultured human brain microvascular endothelial cells ... Read more...

Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor.

Aug 2009 BACKGROUND: Response gene to complement 32 (RGC-32) is induced by activation of complement and regulates cell proliferation. To determine the mechanism of RGC-32 in angiogenesis, we examined the role of RGC-32 in hypoxia-related endothelial cell ... Read more...

Fibroblast growth factor-2 regulates the stability of nuclear bodies.

15 Jul 2009 Nuclear bodies are distinct subnuclear structures. The survival of motoneuron (SMN) gene is mutated or deleted in patients with the neurodegenerative disease spinal muscular atrophy (SMA). The gene product SMN is a marker protein for one class of ... Read more...

Latest indexed articles for 'Fibroblast Growth Factor 2 - Physiology'

These are the very latest articles for this heading:

• Suppression of fibroblast growth factor-2 expression: possible mechanism underlying methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells. 29 Sep 2009
• Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. Aug 2009
• Fibroblast growth factor-2 regulates the stability of nuclear bodies. 15 Jul 2009
• FGF2 modulates the voltage-dependent K+ current and changes excitability of rat dentate gyrus granule cells. 14 Jul 2009
• Local regulation of corpus luteum development and regression in the cow: Impact of angiogenic and vasoactive factors. 29 Jun 2009
• Basic fibroblast growth factor induces down-regulation of alpha-smooth muscle actin and reduction of myofibroblast areas in open skin wounds. 29 Jun 2009
• Erk1/2 promotes proliferation and inhibits neuronal differentiation of neural stem cells. 15 Jun 2009
• Induction of new bone by basic FGF-loaded porous carbonate apatite implants in femur defects in rats. 30 May 2009
• Fibroblast growth factor 2 reactivates G1 checkpoint in SK-N-MC cells via regulation of p21, inhibitor of differentiation genes (Id1-3), and epithelium-mesenchyme transition-like events. 26 May 2009
• Tetrandrine suppresses tumor growth and angiogenesis of gliomas in rats. 13 May 2009
• [Bone fracture and the healing mechanisms. Fibroblast growth factor-2 and fracture healing] 29 Apr 2009
• The tumor suppressor function of human sulfatase 1 (SULF1) in carcinogenesis. 15 Apr 2009
• Fibroblast growth factor-2 autofeedback regulation in pituitary folliculostellate TtT/GF cells. 7 Apr 2009
• HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. 5 Apr 2009
• Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin. 30 Mar 2009
• Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling. 29 Mar 2009
• Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. 23 Mar 2009
• Serum YKL-40 and bone marrow angiogenesis in multiple myeloma. 13 Mar 2009
• Interactions between extracellular matrix and growth factors in wound healing. 27 Feb 2009
• Is angiogenesis essential for the progression of hematological malignancies or is it an epiphenomenon? 27 Feb 2009

See a longer list of these articles.

Technical information about 'Fibroblast Growth Factor 2'

Definition: A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).

Registry Number: 103107-01-3

Descriptor UI: D016222

Alternative terms: Fibroblast Growth Factor 2; Cartilage-Derived Growth Factor; Cartilage Derived Growth Factor; Class II Heparin-Binding Growth Factor; FGF-2; FGF 2; Prostatropin; Fibroblast Growth Factor, Basic; Fibroblast Growth Factor-2; HBGF-2; Heparin-Binding Growth Factor Class II; Prostate Epithelial Cell Growth Factor; Basic Fibroblast Growth Factor; FGF2;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; ultrastructure;

Tree Number: D12.644.276.624.120; D12.776.467.624.120; D23.529.624.120;

History Note: 2001(1991); for FIBROBLAST GROWTH FACTOR-2 use FIBROBLAST GROWTH FACTOR 2 (NM) 1995; for PROSTATROPIN use FIBROBLAST GROWTH FACTOR 2 (NM) 1986-2001

Technical Notes: DF: FGFB