Fibronectins - Biosynthesis
Research News and Information

Monday, November 23, 2009

Thrombospondin-2 therapy ameliorates experimental glomerulonephritis via inhibition of cell proliferation, inflammation, and TGF-beta activation.

31 Aug 2009 We recently identified thrombospondin-2 (TSP-2) as an endogenous regulator of matrix remodelling and inflammation in experimental kidney disease by studying TSP-2-deficient mice. In this study, we asked whether systemic TSP-2 overexpression via ... Read more...

Angiotensin II receptor blockade improves matrix metalloproteinases/tissue inhibitor of matrix metalloproteinase-1 balance and restores fibronectin expression in rat infarcted myocardium.

16 Aug 2009 Matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs) have been recognized to play a pivotal role in matrix remodeling following myocardial infarction (MI). The aims of the present study were to examine the expression profile of ... Read more...

The fibrotic phenotype induced by IGFBP-5 is regulated by MAPK activation and egr-1-dependent and -independent mechanisms.

21 Jul 2009 We have previously shown that insulin-like growth factor (IGF) binding protein- 5 (IGFBP-5) is overexpressed in lung fibrosis and induces the production of extracellular matrix components, such as collagen and fibronectin, both in vitro and in vivo. ... Read more...

Latest indexed articles for 'Fibronectins - Biosynthesis'

These are the very latest articles for this heading:

• Thrombospondin-2 therapy ameliorates experimental glomerulonephritis via inhibition of cell proliferation, inflammation, and TGF-beta activation. 31 Aug 2009
• Angiotensin II receptor blockade improves matrix metalloproteinases/tissue inhibitor of matrix metalloproteinase-1 balance and restores fibronectin expression in rat infarcted myocardium. 16 Aug 2009
• The fibrotic phenotype induced by IGFBP-5 is regulated by MAPK activation and egr-1-dependent and -independent mechanisms. 21 Jul 2009
• Regulation of glucose uptake in mesangial cells stimulated by high glucose: role of angiotensin II and insulin. 20 Jun 2009
• The expression of receptivity markers in the fallopian tube epithelium. 21 Apr 2009
• Pancreatic carcinoma cells stimulate proliferation and matrix synthesis of hepatic stellate cells. 20 Apr 2009
• Enhancement of fibroblast proliferation, collagen biosynthesis and production of growth factors as a result of combining sodium hyaluronate and aminoacids. 30 Mar 2009
• Opposite effect of fluticasone and salmeterol on fibronectin and tenascin-C expression in primary human lung fibroblasts. 18 Mar 2009
• Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to connective tissue growth factor/CCN2 because of an increase in the levels of endogenous fibronectin. 7 Mar 2009
• Genetic deletion of the angiotensin-(1-7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria. 2 Mar 2009
• Mislocalized scaffolding by the Na-H exchanger NHE1 dominantly inhibits fibronectin production and TGF-beta activation. 16 Feb 2009
• Possible involvement of BRAFV600E in altered gene expression in papillary thyroid cancer. 2 Feb 2009
• [Utility of the determination of the foetal fibronectina in pregnancies of 40 weeks or more to predict the beginning of labor] 30 Jan 2009
• Effects of PI3-k/Akt short hairpin RNA on proliferation, fibronectin production and synthesis of thrombospondin-1 and transforming growth factor-beta1 in glomerular mesangial cells induced by sublytic C5b-9 complexes. 30 Jan 2009
• Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients. 6 Jan 2009
• Novel polymer blends for the preparation of membranes for biohybrid liver systems. 30 Dec 2008
• Ultrastructural features of lung fibroblast differentiation into myofibroblasts. 30 Dec 2008
• Influence of microgroove dimension on cell behavior of human gingival fibroblasts cultured on titanium substrata. 30 Dec 2008
• Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines. 30 Dec 2008
• Glutathione redox regulates TGF-beta-induced fibrogenic effects through Smad3 activation. 23 Dec 2008

See a longer list of these articles.

Technical information about 'Fibronectins'

Definition: Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.

Registry Number: 0

Descriptor UI: D005353

Alternative terms: Fibronectins; Opsonic alpha(2)SB Glycoprotein; Opsonic Glycoprotein; Glycoprotein, Opsonic; LETS Proteins; Proteins, LETS; alpha 2-Surface Binding Glycoprotein; alpha 2 Surface Binding Glycoprotein; Fibronectin; Cold-Insoluble Globulins; Cold Insoluble Globulins; Globulins, Cold-Insoluble;

Related Mesh Headings: Receptors, Fibronectin;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.377.715.390; D12.776.395.550.350; D12.776.543.550.350; D12.776.860.300.450;

History Note: 80

Technical Notes: extracellular matrix proteins; /biosyn /physiol permitted