Fibronectins - Genetics
Research News and Information

Sunday, November 22, 2009

Thrombospondin-2 therapy ameliorates experimental glomerulonephritis via inhibition of cell proliferation, inflammation, and TGF-beta activation.

31 Aug 2009 We recently identified thrombospondin-2 (TSP-2) as an endogenous regulator of matrix remodelling and inflammation in experimental kidney disease by studying TSP-2-deficient mice. In this study, we asked whether systemic TSP-2 overexpression via ... Read more...

Co-transcriptional splicing of constitutive and alternative exons.

3 Aug 2009 In metazoan organisms, pre-mRNA splicing is thought to occur during transcription, and it is postulated that these two processes are functionally coupled via still-unknown mechanisms. Current evidence supports co-transcriptional spliceosomal ... Read more...

The orphan nuclear receptor SHP attenuates renal fibrosis.

28 Jul 2009 The accumulation of extracellular matrix proteins is a common feature of fibrotic kidney diseases. Accumulating evidence suggests that TGF-beta and plasminogen activator inhibitor type 1 (PAI-1) promote the development of renal fibrosis by ... Read more...

Latest indexed articles for 'Fibronectins - Genetics'

These are the very latest articles for this heading:

• Thrombospondin-2 therapy ameliorates experimental glomerulonephritis via inhibition of cell proliferation, inflammation, and TGF-beta activation. 31 Aug 2009
• Co-transcriptional splicing of constitutive and alternative exons. 3 Aug 2009
• The orphan nuclear receptor SHP attenuates renal fibrosis. 28 Jul 2009
• Structural basis for exquisite specificity of affinity clamps, synthetic binding proteins generated through directed domain-interface evolution. 28 Jul 2009
• MicroRNA MiR-17 retards tissue growth and represses fibronectin expression. 24 Jul 2009
• Fibronectin binds and enhances the activity of bone morphogenetic protein 1. 16 Jul 2009
• Fibronectin is a TH1-specific molecule in human subjects. 7 Jul 2009
• Pancreatic stellate cells and pancreatic carcinoma: an unholy alliance. 4 Jul 2009
• Leptin and endothelin-1 mediated increased extracellular matrix protein production and cardiomyocyte hypertrophy in diabetic heart disease. 29 Jun 2009
• Control of alternative splicing through siRNA-mediated transcriptional gene silencing. 19 Jun 2009
• Supplemental calcium attenuates the colitis-related increase in diarrhea, intestinal permeability, and extracellular matrix breakdown in HLA-B27 transgenic rats. 15 Jun 2009
• Manganese inhibits the ability of astrocytes to promote neuronal differentiation. 10 Jun 2009
• Stiff skin syndrome: evidence for an inflammation-independent fibrosis? 23 May 2009
• Transient opening of fibronectin type III (FNIII) domains: the interaction of the third FNIII domain of FN with anastellin. 17 May 2009
• Long-term treatment of sirolimus but not cyclosporine ameliorates diabetic nephropathy in the rat. 13 May 2009
• DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation. 13 May 2009
• The role of c-Jun N-terminal kinases 1/2 in transforming growth factor beta(1)-induced expression of connective tissue growth factor and scar formation in the cornea. 29 Apr 2009
• PLC-gamma1 regulates fibronectin assembly and cell aggregation. 16 Apr 2009
• LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. 12 Apr 2009
• Motogenic sites in human fibronectin are masked by long range interactions. 12 Apr 2009

See a longer list of these articles.

Technical information about 'Fibronectins'

Definition: Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.

Registry Number: 0

Descriptor UI: D005353

Alternative terms: Fibronectins; Opsonic alpha(2)SB Glycoprotein; Opsonic Glycoprotein; Glycoprotein, Opsonic; LETS Proteins; Proteins, LETS; alpha 2-Surface Binding Glycoprotein; alpha 2 Surface Binding Glycoprotein; Fibronectin; Cold-Insoluble Globulins; Cold Insoluble Globulins; Globulins, Cold-Insoluble;

Related Mesh Headings: Receptors, Fibronectin;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.377.715.390; D12.776.395.550.350; D12.776.543.550.350; D12.776.860.300.450;

History Note: 80

Technical Notes: extracellular matrix proteins; /biosyn /physiol permitted