Flavonoids - Pharmacology
Research News and Information

Sunday, November 22, 2009

Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB.

13 Nov 2009 Death receptors of the tumor necrosis factor (TNF) receptor super family have been implicated in constitutive activation of nuclear factor-kappa B (NF-kappaB) in pancreatic cancer (PaC) cells. In this study, we demonstrate that fisetin, a natural ... Read more...

Nutrition, brain aging, and neurodegeneration.

12 Oct 2009 The onset of age-related neurodegenerative diseases superimposed on a declining nervous system could enhance the motor and cognitive behavioral deficits that normally occur in senescence. It is likely that, in cases of severe deficits in memory or ... Read more...

Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease.

29 Sep 2009 This randomized, double-blind, parallel trial assessed the influence of pomegranate juice consumption on anterior and posterior carotid intima-media thickness (CIMT) progression rates in subjects at moderate risk for coronary heart disease. Subjects ... Read more...

Latest indexed articles for 'Flavonoids - Pharmacology'

These are the very latest articles for this heading:

• Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB. 13 Nov 2009
• Nutrition, brain aging, and neurodegeneration. 12 Oct 2009
• Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease. 29 Sep 2009
• Amino and nitro derivatives of 5,7-dimethoxyflavone from Kaempferia parviflora and cytotoxicity against KB cell line. 24 Sep 2009
• Structural modification of 5,7-dimethoxyflavone from Kaempferia parviflora and biological activities. 24 Sep 2009
• Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. 20 Sep 2009
• Therapeutic use of tea derivatives: all that glitters is not gold. 8 Sep 2009
• Simultaneous detection of ERK-, p38-, and JNK-MAPK phosphorylation in human adipose-derived stem cells using the Cytometric Bead Array technology. Sep 2009
• Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family. 30 Aug 2009
• Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts. 30 Aug 2009
• Triterpenoids and flavonoids from celery (Apium graveolens). 30 Aug 2009
• Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. 30 Aug 2009
• Molecular mechanisms underlying the flavonoid-induced inhibition of alpha-synuclein fibrillation. 30 Aug 2009
• Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes. 30 Aug 2009
• S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4. 25 Aug 2009
• A cellular model to monitor proteasome dysfunction by alpha-synuclein. 23 Aug 2009
• Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: probing the active site of the enzyme with molecular modeling and site-directed mutagenesis. 21 Aug 2009
• DNA synthesis of rat bone marrow mesenchymal stem cells through alpha1-adrenergic receptors. 16 Aug 2009
• Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells. 11 Aug 2009
• A [3]ferrocenophane polyphenol showing a remarkable antiproliferative activity on breast and prostate cancer cell lines. 11 Aug 2009

See a longer list of these articles.

Technical information about 'Flavonoids'

Definition: A group of phenyl benzopyrans named for having structures like FLAVONES.

Registry Number: 0

Descriptor UI: D005419

Alternative terms: Flavonoids; 2-Phenyl-Chromenes; 2 Phenyl Chromenes; 2-Phenyl-Benzopyrans; 2 Phenyl Benzopyrans; Bioflavonoids;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.438.150.266.450; D03.830.219.266.450;

History Note: 2004(1963)

Technical Notes: do not confuse with FLAVINS, pigments