Flunitrazepam - Pharmacology
Research News and Information

Sunday, November 22, 2009

Chronic effects of flunitrazepam on shock-induced behavioral inhibition in adult male rats.

14 May 2009 Flunitrazepam has been reported to trigger cases of extreme violence in man and recently it was shown to heighten aggression in experimental rats. The underlying mechanisms may involve disinhibited/impulsive behavior. Here, tolerance developed to ... Read more...

The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices.

30 Mar 2009 BACKGROUND: Urotensin II (UII) and its receptor (UT) are implicated in mood disorders, such as stress and anxiety, and this may result, at least in part, from increased norepinephrine release from the cerebral cortex. Benzodiazepines have been ... Read more...

Selective changes in sensitivity to benzodiazepines, and not other positive GABA(A) modulators, in rats receiving flunitrazepam chronically.

8 Mar 2009 RATIONALE: Tolerance and dependence can develop during chronic benzodiazepine treatment; however, cross tolerance and cross dependence to positive modulators acting at other sites on GABA(A) receptors might not occur. OBJECTIVES: The current study ... Read more...

Latest indexed articles for 'Flunitrazepam - Pharmacology'

These are the very latest articles for this heading:

• Chronic effects of flunitrazepam on shock-induced behavioral inhibition in adult male rats. 14 May 2009
• The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices. 30 Mar 2009
• Selective changes in sensitivity to benzodiazepines, and not other positive GABA(A) modulators, in rats receiving flunitrazepam chronically. 8 Mar 2009
• Triton X-100 inhibits agonist-induced currents and suppresses benzodiazepine modulation of GABA(A) receptors in Xenopus oocytes. 10 Feb 2009
• Relative potency and effectiveness of flunitrazepam, ethanol, and beta-CCE for disrupting the acquisition and retention of response sequences in rats. 30 Jan 2009
• A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells. 29 Nov 2008
• Metabolic activation of benzodiazepines by CYP3A4. 10 Nov 2008
• Behavioral pharmacological properties after recovery from the loss of righting reflex induced by benzodiazepine receptor agonists in mice. 29 Sep 2008
• Menthol shares general anesthetic activity and sites of action on the GABA(A) receptor with the intravenous agent, propofol. 5 Jun 2008
• [Flunitrazepame--report based on experience with a dangerous drug] 8 Apr 2008
• Differentiating the discriminative stimulus effects of gamma-hydroxybutyrate and ethanol in a three-choice drug discrimination procedure in rats. 21 Feb 2008
• Heightened aggression after chronic flunitrazepam in male rats: potential links to cortical and caudate-putamen-binding sites. 12 Dec 2007
• Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. 11 Nov 2007
• Translocator protein (18 kDa) ligand PK 11195 induces transient mitochondrial Ca2+ release leading to transepithelial Cl- secretion in HT-29 human colon cancer cells. 30 Oct 2007
• Modulation of human risky decision making by flunitrazepam. 3 Oct 2007
• Neonatal maternal separation and enhancement of the hypoxic ventilatory response in rat: the role of GABAergic modulation within the paraventricular nucleus of the hypothalamus. 12 Jun 2007
• Modification of ethanol's reinforcing effectiveness in rhesus monkeys by cocaine, flunitrazepam, or gamma-hydroxybutyrate. 16 May 2007
• Phosphatidylinositol 4,5-bisphosphate induced flunitrazepam sensitive-GABAA receptor increase in synaptosomes from chick forebrain. 29 Mar 2007
• Characterization of two classes of benzodiazepine binding sites in Schistosoma mansoni. 20 Feb 2007
• Effects of gamma-hydroxybutyric acid and flunitrazepam on ethanol intake in male rats. 6 Jan 2007

See a longer list of these articles.

Technical information about 'Flunitrazepam'

Definition: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.

Chemical name: 2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-

Registry Number: 1622-62-4

Descriptor UI: D005445

Alternative terms: Flunitrazepam; Fluridrazepam; flunizep von ct; ct-Arzneimittel Brand of Flunitrazepam; ct Arzneimittel Brand of Flunitrazepam; RO-5-4200; RO54200; Rohypnol; Rohipnol; Roche Brand of Flunitrazepam; Narcozep; Fluni 1A Pharma; 1A Brand of Flunitrazepam; Flunitrazepam-ratiopharm; Flunitrazepam ratiopharm; ratiopharm Brand of Flunitrazepam; Flunimerck; Merck dura Brand of Flunitrazepam; Fluninoc; Hexal Brand of Flunitrazepam; Flunitrazepam-neuraxpharm; Flunitrazepam neuraxpharm; neuraxpharm Brand of Flunitrazepam; Flunitrazepam-Teva; Flunitrazepam Teva; Teva Brand of Flunitrazepam; Flunibeta; betapharm Brand of Flunitrazepam;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: GABA Modulators; Anti-Anxiety Agents;

Tree Number: D03.438.079.080.070.320;

History Note: 84(75); was see under BENZODIAZEPINE TRANQUILIZERS 1975-83

Technical Notes: colloquially called "rophies" & "roofies" from X ref ROHYPNOL