Flunitrazepam
Research News and Information

Sunday, November 22, 2009

Epidemic of poisoning caused by scopolamine disguised as Rohypnol tablets.

30 Oct 2009 OBJECTIVE: An epidemic of scopolamine poisonings occurred in Oslo in 2008 among users of illicit drugs, caused by fake Rohypnol pills. The clinical features, diagnostic process, and handling of the epidemic are presented. METHODS: Suspected cases of ... Read more...

Chronic effects of flunitrazepam on shock-induced behavioral inhibition in adult male rats.

14 May 2009 Flunitrazepam has been reported to trigger cases of extreme violence in man and recently it was shown to heighten aggression in experimental rats. The underlying mechanisms may involve disinhibited/impulsive behavior. Here, tolerance developed to ... Read more...

The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices.

30 Mar 2009 BACKGROUND: Urotensin II (UII) and its receptor (UT) are implicated in mood disorders, such as stress and anxiety, and this may result, at least in part, from increased norepinephrine release from the cerebral cortex. Benzodiazepines have been ... Read more...

Latest indexed articles for 'Flunitrazepam'

These are the very latest articles for this heading:

• Epidemic of poisoning caused by scopolamine disguised as Rohypnol tablets. 30 Oct 2009
• Chronic effects of flunitrazepam on shock-induced behavioral inhibition in adult male rats. 14 May 2009
• The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices. 30 Mar 2009
• Characterization of Escherichia coli nitroreductase NfsB in the metabolism of nitrobenzodiazepines. 29 Mar 2009
• Selective changes in sensitivity to benzodiazepines, and not other positive GABA(A) modulators, in rats receiving flunitrazepam chronically. 8 Mar 2009
• Triton X-100 inhibits agonist-induced currents and suppresses benzodiazepine modulation of GABA(A) receptors in Xenopus oocytes. 10 Feb 2009
• Relative potency and effectiveness of flunitrazepam, ethanol, and beta-CCE for disrupting the acquisition and retention of response sequences in rats. 30 Jan 2009
• The detection of various opiates and benzodiazepines by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry. 30 Jan 2009
• Automated polyvinylidene difluoride hollow fiber liquid-phase microextraction of flunitrazepam in plasma and urine samples for gas chromatography/tandem mass spectrometry. 13 Jan 2009
• [The knowledge about "date rape drugs" among Polish students] 30 Dec 2008
• Determination of 7-aminoflunitrazepam in urine by dispersive liquid-liquid microextraction with liquid chromatography-electrospray-tandem mass spectrometry. 22 Dec 2008
• Development and validation of a liquid chromatography-atmospheric pressure photoionization-mass spectrometry method for the quantification of alprazolam, flunitrazepam, and their main metabolites in haemolysed blood. 4 Dec 2008
• A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells. 29 Nov 2008
• Metabolic activation of benzodiazepines by CYP3A4. 10 Nov 2008
• Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets. 30 Oct 2008
• Chemical submission: results of 4-year French inquiry. 15 Oct 2008
• Prevention of drug-induced memory impairment by immunopharmacotherapy. 14 Oct 2008
• Differential effects of diazepam treatment and withdrawal on recombinant GABAA receptor expression and functional coupling. 13 Oct 2008
• [Abuse of alcohol and benzodiazepine during substitution therapy in heroin addicts: a review of the literature] 29 Sep 2008
• Behavioral pharmacological properties after recovery from the loss of righting reflex induced by benzodiazepine receptor agonists in mice. 29 Sep 2008

See a longer list of these articles.

Technical information about 'Flunitrazepam'

Definition: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.

Chemical name: 2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-

Registry Number: 1622-62-4

Descriptor UI: D005445

Alternative terms: Flunitrazepam; Fluridrazepam; flunizep von ct; ct-Arzneimittel Brand of Flunitrazepam; ct Arzneimittel Brand of Flunitrazepam; RO-5-4200; RO54200; Rohypnol; Rohipnol; Roche Brand of Flunitrazepam; Narcozep; Fluni 1A Pharma; 1A Brand of Flunitrazepam; Flunitrazepam-ratiopharm; Flunitrazepam ratiopharm; ratiopharm Brand of Flunitrazepam; Flunimerck; Merck dura Brand of Flunitrazepam; Fluninoc; Hexal Brand of Flunitrazepam; Flunitrazepam-neuraxpharm; Flunitrazepam neuraxpharm; neuraxpharm Brand of Flunitrazepam; Flunitrazepam-Teva; Flunitrazepam Teva; Teva Brand of Flunitrazepam; Flunibeta; betapharm Brand of Flunitrazepam;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: GABA Modulators; Anti-Anxiety Agents;

Tree Number: D03.438.079.080.070.320;

History Note: 84(75); was see under BENZODIAZEPINE TRANQUILIZERS 1975-83

Technical Notes: colloquially called "rophies" & "roofies" from X ref ROHYPNOL