Fluoxetine - Pharmacology
Research News and Information

Sunday, November 22, 2009

Antidepressant actions of histone deacetylase inhibitors.

14 Sep 2009 Persistent symptoms of depression suggest the involvement of stable molecular adaptations in brain, which may be reflected at the level of chromatin remodeling. We find that chronic social defeat stress in mice causes a transient decrease, followed ... Read more...

Antidepressant medication use during breastfeeding.

30 Aug 2009 We performed an electronic search by using MEDLINE, PreMEDLINE, Current Contents, Biological Abstracts, and PsycINFO from June 2002 to December 2008 using the following terms: "antidepressant drugs", "antidepressive agents", "human milk", ... Read more...

Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes.

27 Jul 2009 Serotonin transporter (SERT) is the main target for widely used antidepressant agents. Several of these drugs, including imipramine, citalopram, sertraline, and fluoxetine (Prozac), bound more avidly to SERT in the presence of Cl(-). In contrast, ... Read more...

Latest indexed articles for 'Fluoxetine - Pharmacology'

These are the very latest articles for this heading:

• Antidepressant actions of histone deacetylase inhibitors. 14 Sep 2009
• Antidepressant medication use during breastfeeding. 30 Aug 2009
• Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes. 27 Jul 2009
• Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes. 15 Jul 2009
• Ondansetron and fluoxetine reduce sleep apnea in mice lacking monoamine oxidase A. 13 Jul 2009
• Induction of neuronal vascular endothelial growth factor expression by cAMP in the dentate gyrus of the hippocampus is required for antidepressant-like behaviors. 29 Jun 2009
• Neurosteroids modulate compulsive and persistent behavior in rodents: implications for obsessive-compulsive disorder. 19 Jun 2009
• Use of latency to immobility improves detection of antidepressant-like activity in the behavioral despair test in the mouse. 19 Jun 2009
• Rostral anterior cingulate cortex theta current density and response to antidepressants and placebo in major depression. 15 Jun 2009
• Blocked inhibitory serine-phosphorylation of glycogen synthase kinase-3alpha/beta impairs in vivo neural precursor cell proliferation. 9 Jun 2009
• Cost-effectiveness of quetiapine plus mood stabilizers compared with mood stabilizers alone in the maintenance therapy of bipolar I disorder: results of a Markov model analysis. 30 May 2009
• Serotonin 5-HT1A and 5-HT3 receptors in an impulsive-aggressive phenotype. 30 May 2009
• Dissecting the pathophysiology of depression with a Swiss army knife. 26 May 2009
• Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity. 12 May 2009
• Paradoxical anxiogenic response of juvenile mice to fluoxetine. 11 May 2009
• Early raise of BDNF in hippocampus suggests induction of posttranscriptional mechanisms by antidepressants. 11 May 2009
• Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. 8 May 2009
• Fluoxetine attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. 5 May 2009
• Evaluation of antidepressant like property of amisulpride per se and its comparison with fluoxetine and olanzapine using forced swimming test in albino mice. 29 Apr 2009
• The effect of increased serotonergic neurotransmission on aggression: a critical meta-analytical review of preclinical studies. 28 Apr 2009

See a longer list of these articles.

Technical information about 'Fluoxetine'

Definition: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.

Chemical name: Benzenepropanamine, N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)-

Registry Number: 54910-89-3

Descriptor UI: D005473

Alternative terms: Fluoxetine; N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; Fluoxetin; Sarafem; Prozac; Fluoxetine Hydrochloride; Lilly-110140; Lilly 110140; Lilly110140;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Serotonin Uptake Inhibitors; Antidepressive Agents, Second-Generation;

Tree Number: D02.092.831.280;

Online Note: use FLUOXETINE to search FLUOXETIN 1979-89

History Note: 90(79); was FLUOXETIN see under PROPYLAMINES 1979-88; was FLUOXETIN 1989