Flupenthixol - Pharmacology
Research News and Information

Tuesday, November 24, 2009

Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat.

29 Sep 2009 Male rats display a conditioned preference to ejaculate with a female bearing an odor paired previously with copulation to ejaculation. The present study examined the role of endogenous opioid and dopamine systems in this preference. Male rats ... Read more...

Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats.

26 May 2009 The neural mechanisms underlying the transition from a drug-nondependent to a drug-dependent state remain elusive. Chronic exposure to drugs has been shown to increase brain-derived neurotrophic factor (BDNF) levels in ventral tegmental area (VTA) ... Read more...

A role for medial prefrontal dopaminergic innervation in instrumental conditioning.

18 May 2009 To investigate the involvement of dopaminergic projections to the prelimbic and infralimbic cortex in the control of goal-directed responses, a first experiment examined the effect of pretraining 6-OHDA lesions of these cortices. We used outcome ... Read more...

Latest indexed articles for 'Flupenthixol - Pharmacology'

These are the very latest articles for this heading:

• Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat. 29 Sep 2009
• Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats. 26 May 2009
• A role for medial prefrontal dopaminergic innervation in instrumental conditioning. 18 May 2009
• Chronic nicotine exposure switches the functional role of mesolimbic dopamine transmission in the processing of nicotine's rewarding and aversive effects. 27 Feb 2009
• Contribution of dopamine receptors to periaqueductal gray-mediated antinociception. 17 Feb 2009
• Involvement of dopamine and opioids in the motivation to eat: influence of palatability, homeostatic state, and behavioral paradigms. 16 Nov 2008
• Involvement of amygdala dopamine and nucleus accumbens NMDA receptors in ethanol-seeking behavior in mice. 29 Sep 2008
• Distinct contributions of dopamine receptors in the nucleus accumbens core or shell to established cocaine reinforcement under a second-order schedule. 26 Aug 2008
• Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity. 26 Aug 2008
• Behavioral responses of dopamine beta-hydroxylase knockout mice to modafinil suggest a dual noradrenergic-dopaminergic mechanism of action. 23 Jul 2008
• Neurochemical basis of conditioned partner preference in the female rat: II. Disruption by flupenthixol. 30 Mar 2008
• Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. 5 Feb 2008
• Bidirectional cannabinoid modulation of social behavior in adolescent rats. 4 Dec 2007
• Dopaminergic modulation of reproductive behavior and activity in male zebra finches. 10 Sep 2007
• Dopaminergic and glutamatergic regulation of effort- and delay-based decision making. 3 Sep 2007
• Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys. 13 May 2007
• Medial prefrontal cortex infusion of alpha-flupenthixol attenuates systemic d-amphetamine-induced disruption of conditional discrimination performance in rats. 6 Feb 2007
• Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol. Feb 2007
• Clozapine, SCH 23390 and alpha-flupenthixol but not haloperidol attenuate acute phencyclidine-induced disruption of conditional discrimination performance. 18 Jan 2007
• Fecal bulking in a frequently mated female rat. Colonic obstruction due to severe vaginal distension. 30 Oct 2006

See a longer list of these articles.

Technical information about 'Flupenthixol'

Definition: A thioxanthene neuroleptic that, unlike CHLORPROMAZINE, is claimed to have CNS-activating properties. It is used in the treatment of psychoses although not in excited or manic patients. (From Martindale, The Extra Pharmacopoeia, 30th ed, p595)

Chemical name: 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-

Registry Number: 2709-56-0

Descriptor UI: D005475

Alternative terms: Flupenthixol; Flupentixol; alpha-Flupenthixol; cis-Flupenthixol; Emergil; Fluanxol;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Dopamine Antagonists; Antipsychotic Agents;

Tree Number: D02.886.952.360; D03.383.606.460; D03.494.953.704.360;

History Note: 91(75); was see under THIOXANTHENES 1975-90