Flupenthixol
Research News and Information

Sunday, November 22, 2009

Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat.

29 Sep 2009 Male rats display a conditioned preference to ejaculate with a female bearing an odor paired previously with copulation to ejaculation. The present study examined the role of endogenous opioid and dopamine systems in this preference. Male rats ... Read more...

Involvement of Basal Ganglia network in motor disabilities induced by typical antipsychotics.

7 Jul 2009 BACKGROUND: Clinical treatments with typical antipsychotic drugs (APDs) are accompanied by extrapyramidal motor side-effects (EPS) such as hypokinesia and catalepsy. As little is known about electrophysiological substrates of such motor ... Read more...

Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats.

26 May 2009 The neural mechanisms underlying the transition from a drug-nondependent to a drug-dependent state remain elusive. Chronic exposure to drugs has been shown to increase brain-derived neurotrophic factor (BDNF) levels in ventral tegmental area (VTA) ... Read more...

Latest indexed articles for 'Flupenthixol'

These are the very latest articles for this heading:

• Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat. 29 Sep 2009
• Involvement of Basal Ganglia network in motor disabilities induced by typical antipsychotics. 7 Jul 2009
• Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats. 26 May 2009
• A role for medial prefrontal dopaminergic innervation in instrumental conditioning. 18 May 2009
• Chronic nicotine exposure switches the functional role of mesolimbic dopamine transmission in the processing of nicotine's rewarding and aversive effects. 27 Feb 2009
• Contribution of dopamine receptors to periaqueductal gray-mediated antinociception. 17 Feb 2009
• Functional interaction between the basolateral amygdala and the nucleus accumbens underlies incentive motivation for food reward on a fixed ratio schedule. 18 Jan 2009
• Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice. 12 Jan 2009
• Involvement of dopamine and opioids in the motivation to eat: influence of palatability, homeostatic state, and behavioral paradigms. 16 Nov 2008
• Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa. 30 Oct 2008
• Involvement of amygdala dopamine and nucleus accumbens NMDA receptors in ethanol-seeking behavior in mice. 29 Sep 2008
• [Development of a method for determining antidepressant drugs in nails and its usefulness in forensic toxicology] 29 Sep 2008
• Distinct contributions of dopamine receptors in the nucleus accumbens core or shell to established cocaine reinforcement under a second-order schedule. 26 Aug 2008
• Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity. 26 Aug 2008
• Behavioral responses of dopamine beta-hydroxylase knockout mice to modafinil suggest a dual noradrenergic-dopaminergic mechanism of action. 23 Jul 2008
• Long-term treatment with flupentixol results of a post-marketing surveillance study. 16 Jun 2008
• Antipsychotic polypharmacy in the emergency treatment of highly aggressive schizophrenic prisoners - a retrospective study. 30 May 2008
• Neurochemical basis of conditioned partner preference in the female rat: II. Disruption by flupenthixol. 30 Mar 2008
• Clinical trial: a randomized controlled cross-over study of flupenthixol + melitracen in functional dyspepsia. 8 Mar 2008
• Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. 5 Feb 2008

See a longer list of these articles.

Technical information about 'Flupenthixol'

Definition: A thioxanthene neuroleptic that, unlike CHLORPROMAZINE, is claimed to have CNS-activating properties. It is used in the treatment of psychoses although not in excited or manic patients. (From Martindale, The Extra Pharmacopoeia, 30th ed, p595)

Chemical name: 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-

Registry Number: 2709-56-0

Descriptor UI: D005475

Alternative terms: Flupenthixol; Flupentixol; alpha-Flupenthixol; cis-Flupenthixol; Emergil; Fluanxol;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Dopamine Antagonists; Antipsychotic Agents;

Tree Number: D02.886.952.360; D03.383.606.460; D03.494.953.704.360;

History Note: 91(75); was see under THIOXANTHENES 1975-90