Forkhead Transcription Factors - Metabolism
Research News and Information

Monday, November 23, 2009

FoxP3+ regulatory T cells are distinct from leukemia cells in HTLV-1-associated adult T-cell leukemia.

13 Nov 2009 Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATLL). It has been postulated that ATLL cells might act as regulatory T cells (T(regs)) which, in common with ATLL cells, express both CD25 and ... Read more...

Runx proteins regulate Foxp3 expression.

17 Oct 2009 Runx proteins are essential for hematopoiesis and play an important role in T cell development by regulating key target genes, such as CD4 and CD8 as well as lymphokine genes, during the specialization of naive CD4 T cells into distinct T helper ... Read more...

Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions.

13 Oct 2009 Pigment epithelium isolated from the eye possesses immunosuppressive properties such as regulatory T (Treg) cell induction; e.g., cultured retinal pigment epithelium (RPE) converts CD4(+) T cells into Treg cells in vitro. RPE constitutively ... Read more...

Latest indexed articles for 'Forkhead Transcription Factors - Metabolism'

These are the very latest articles for this heading:

• FoxP3+ regulatory T cells are distinct from leukemia cells in HTLV-1-associated adult T-cell leukemia. 13 Nov 2009
• FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome. 20 Oct 2009
• Runx proteins regulate Foxp3 expression. 17 Oct 2009
• Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. 13 Oct 2009
• Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone. 10 Oct 2009
• Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. 4 Oct 2009
• Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes. 3 Oct 2009
• Targeted therapy to the IL-2R using diphtheria toxin and caspase-3 fusion proteins modulates Treg and ameliorates inflammatory colitis. 29 Sep 2009
• Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4(+)CD25(+)Foxp3(+) Treg in mice. 29 Sep 2009
• Allogeneic induced human FOXP3(+)IFN-gamma(+) T cells exhibit selective suppressive capacity. 29 Sep 2009
• Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function. 29 Sep 2009
• Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. 29 Sep 2009
• The CD4(+)CD8(+) and CD4(+) subsets of FOXP3(+) thymocytes differ in their response to growth factor deprivation or stimulation. 29 Sep 2009
• The FOXF2 pathway in the human prostate stroma. 29 Sep 2009
• Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients. 29 Sep 2009
• Lessons from thymic epithelial heterogeneity: FoxN1 and tissue-restricted gene expression by extrathymic, endodermally derived epithelium. 26 Sep 2009
• Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. 25 Sep 2009
• Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha. 22 Sep 2009
• The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. 18 Sep 2009
• Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. 18 Sep 2009

See a longer list of these articles.

Technical information about 'Forkhead Transcription Factors'

Definition: A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.

Registry Number: 0

Descriptor UI: D051858

Alternative terms: Forkhead Transcription Factors; Transcription Factors, Forkhead; Fox Transcription Factors; Transcription Factors, Fox; Forkhead Proteins; Forkhead Box Proteins; Forkhead Box Transcription Factors;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.260.950.249; D12.776.930.977.249;

History Note: 2006(1989)