Forkhead Transcription Factors
Research News and Information

Monday, November 23, 2009

FoxP3+ regulatory T cells are distinct from leukemia cells in HTLV-1-associated adult T-cell leukemia.

13 Nov 2009 Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATLL). It has been postulated that ATLL cells might act as regulatory T cells (T(regs)) which, in common with ATLL cells, express both CD25 and ... Read more...

Regulatory T-cells in periapical lesions.

30 Oct 2009 CD4(+)CD25(hi)Foxp3(+) regulatory T-cells (Tregs) are of crucial importance in regulating the immune response, including the control of any defense against infection. Their presence in periapical lesions has not been demonstrated, as yet. We ... Read more...

The gut feeling of Treg cells: IL-10 is the silver lining during colitis.

30 Oct 2009 Regulatory T cells that express the transcription factor Foxp3 are pivotal in suppressing autoimmune responses. A report in this issue describes a key role for interleukin 10 produced by lamina propria macrophages in maintaining Foxp3 expression ... Read more...

Latest indexed articles for 'Forkhead Transcription Factors'

These are the very latest articles for this heading:

• FoxP3+ regulatory T cells are distinct from leukemia cells in HTLV-1-associated adult T-cell leukemia. 13 Nov 2009
• Regulatory T-cells in periapical lesions. 30 Oct 2009
• The gut feeling of Treg cells: IL-10 is the silver lining during colitis. 30 Oct 2009
• FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome. 20 Oct 2009
• Runx proteins regulate Foxp3 expression. 17 Oct 2009
• Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. 13 Oct 2009
• Dominant role of antigen dose in CD4+Foxp3+ regulatory T cell induction and expansion. 13 Oct 2009
• Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone. 10 Oct 2009
• Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. 4 Oct 2009
• Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes. 3 Oct 2009
• Targeted therapy to the IL-2R using diphtheria toxin and caspase-3 fusion proteins modulates Treg and ameliorates inflammatory colitis. 29 Sep 2009
• Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4(+)CD25(+)Foxp3(+) Treg in mice. 29 Sep 2009
• Plasmacytoid DC promote priming of autoimmune Th17 cells and EAE. 29 Sep 2009
• Allogeneic induced human FOXP3(+)IFN-gamma(+) T cells exhibit selective suppressive capacity. 29 Sep 2009
• Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function. 29 Sep 2009
• Cutting edge: CD4-independent development of functional FoxP3+ regulatory T cells. 29 Sep 2009
• Foxp3 expression in lesions of the different clinical forms of American tegumentary leishmaniasis. 29 Sep 2009
• Regulatory T Cells in children with intestinal parasite infection. 29 Sep 2009
• Identification of candidate epigenetic biomarkers for ovarian cancer detection. 29 Sep 2009
• FoxO3a gene is a target of deletion in mouse lung adenocarcinoma. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Forkhead Transcription Factors'

Definition: A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.

Registry Number: 0

Descriptor UI: D051858

Alternative terms: Forkhead Transcription Factors; Transcription Factors, Forkhead; Fox Transcription Factors; Transcription Factors, Fox; Forkhead Proteins; Forkhead Box Proteins; Forkhead Box Transcription Factors;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.260.950.249; D12.776.930.977.249;

History Note: 2006(1989)