Furans - Pharmacokinetics
Research News and Information

Sunday, November 22, 2009

Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats.

9 Mar 2009 A single dose by gavage of bilobalide (30 mg/kg) was found to produce a time-dependent induction of hepatic cytochrome P450 (CYP) enzyme activity and protein expression in rats. An RT-PCR study further showed that mRNA expression of CYP2B was ... Read more...

Characterization of cyclodextrin inclusion complexes of the anti-HIV non-nucleoside reverse transcriptase inhibitor UC781.

15 Dec 2008 The highly potent anti-HIV agent UC781 is being evaluated for use in topical microbicides to prevent HIV transmission. However, UC781 is extremely hydrophobic with poor water solubility, a property that may complicate appropriate formulation of the ... Read more...

Norfuraneol dephosphorylates eNOS at threonine 495 and enhances eNOS activity in human endothelial cells.

24 Nov 2008 AIM: Pentoses are widely abundant in organic food. Thermal treatment of pentoses leads to the formation of norfuraneol (NF). The aim of this study was to show whether NF, which is taken up regularly, for example with cooked food, affects the human ... Read more...

Latest indexed articles for 'Furans - Pharmacokinetics'

These are the very latest articles for this heading:

• Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats. 9 Mar 2009
• Characterization of cyclodextrin inclusion complexes of the anti-HIV non-nucleoside reverse transcriptase inhibitor UC781. 15 Dec 2008
• Norfuraneol dephosphorylates eNOS at threonine 495 and enhances eNOS activity in human endothelial cells. 24 Nov 2008
• Apparent half-lives of dioxins, furans, and polychlorinated biphenyls as a function of age, body fat, smoking status, and breast-feeding. Oct 2008
• Monocationic radiotracer kinetics and myocardial infarct size: a perfused rat heart study. 27 Aug 2008
• Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity. 29 Apr 2008
• Con-A conjugated mucoadhesive microspheres for the colonic delivery of diloxanide furoate. 10 Apr 2008
• Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain. 3 Jan 2008
• Heterotricyclic himbacine analogs as potent, orally active thrombin receptor (protease activated receptor-1) antagonists. 12 Sep 2007
• Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. 19 May 2007
• A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. 30 Apr 2007
• Metabolism of FPP-3, an anti-inflammatory propenone compound, in rat by liquid chromatography-electrospray ionization tandem mass spectrometry. 29 Apr 2007
• Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist. 29 Apr 2007
• C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists. 8 Apr 2007
• Disposition of orally and intravenously administered methyltetrahydrofuran in rats and mice. 30 Mar 2007
• Preclinical safety assessments of UC781 anti-human immunodeficiency virus topical microbicide formulations. 10 Mar 2007
• [Influence of permeation enhancers on transdermal permeation of anemonin] 27 Feb 2007
• Metabolism-based identification of a potent thrombin receptor antagonist. 9 Jan 2007
• Identification of 1-furan-2-yl-3-pyridin-2-yl-propenone, an antiinflammatory agent, and its metabolites in rat liver subcellular fractions. 30 Oct 2006
• Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes. 30 May 2006

See a longer list of these articles.

Technical information about 'Furans'

Definition: Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.

Registry Number: 0

Descriptor UI: D005663

Alternative terms: Furans; Tetrahydrofurans;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.383.312;