Furans - Pharmacology
Research News and Information

Sunday, November 22, 2009

Promoting assembly and bundling of FtsZ as a strategy to inhibit bacterial cell division: a new approach for developing novel antibacterial drugs.

12 Sep 2009 FtsZ plays an essential role in bacterial cell division. We have used the assembly of FtsZ as a screen to find antibacterial agents with a novel mechanism of action. The effects of 81 compounds of 29 different structural scaffolds on FtsZ assembly ... Read more...

Mechanism of action of novel naphthofuranquinones on rat liver microsomal peroxidation.

6 Sep 2009 In order to elucidate the effect on mammal systems of new derivatives from 2-hydroxy-3-allyl-naphthoquinone, alpha-iodinated naphthofuranquinone (NPPN-3223), beta-iodinated naphthofuranquinone (NPPN-3222) and beta-methyl naphthofuranquinone ... Read more...

Gamma-lactones and ent-eudesmane sesquiterpenes from the endophytic fungus Eutypella sp. BCC 13199.

30 Aug 2009 Two new gamma-lactones, eutypellins A (1) and B (2), and two ent-eudesmane sesquiterpenes, ent-4(15)-eudesmen-11-ol-1-one (3) and ent-4(15)-eudesmen-1alpha,11-diol (4), together with three known pimarane diterpenes, diaporthein B, scopararane A, and ... Read more...

Latest indexed articles for 'Furans - Pharmacology'

These are the very latest articles for this heading:

• Promoting assembly and bundling of FtsZ as a strategy to inhibit bacterial cell division: a new approach for developing novel antibacterial drugs. 12 Sep 2009
• Mechanism of action of novel naphthofuranquinones on rat liver microsomal peroxidation. 6 Sep 2009
• Gamma-lactones and ent-eudesmane sesquiterpenes from the endophytic fungus Eutypella sp. BCC 13199. 30 Aug 2009
• Inhibitors of osteoclast formation from rhizomes of Cibotium barometz. 30 Aug 2009
• In vitro and in vivo antiproliferative activity of laherradurin and cherimolin-2 of Annona diversifolia Saff. 30 Jul 2009
• HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA. 26 Jul 2009
• Coumarins from Angelica lucida L.--antibacterial activities. 25 Jul 2009
• The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair. 25 Jul 2009
• Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. 14 Jul 2009
• Biomimetic synthesis of a new class of bacterial signaling molecules. 14 Jul 2009
• Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941. 5 Jul 2009
• Differential use of anhydropyranosides for enantiopure routes to bis-gamma-butyrolactones: a new approach to the frameworks of antibiotic and anticancer agents isoavenaciolide and ethisolide. Jul 2009
• Chloropestolide A, an antitumor metabolite with an unprecedented spiroketal skeleton from Pestalotiopsis fici. 30 Jun 2009
• The halichondrins and E7389. 29 Jun 2009
• Involvement of matrix metalloproteinases in the inhibition of cell invasion and migration through the inhibition of NF-[kappa]B by the new synthesized ethyl 2-[N-p-chlorobenzyl-(2'-methyl)]anilino-4-oxo-4,5-dihydrofuran-3-carboxylate (JOTO1007) in human cervical cancer Ca ski cells. 29 Jun 2009
• A novel dual PI3Kalpha/mTOR inhibitor PI-103 with high antitumor activity in non-small cell lung cancer cells. 29 Jun 2009
• A new cytotoxic spiroketal from the myxobacterium Sorangium cellulosum. 24 Jun 2009
• Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans. 20 Jun 2009
• Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents. 9 Jun 2009
• 7-Oxoorobanchyl acetate and 7-Oxoorobanchol as germination stimulants for root parasitic plants from flax (Linum usitatissimum). 5 Jun 2009

See a longer list of these articles.

Technical information about 'Furans'

Definition: Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.

Registry Number: 0

Descriptor UI: D005663

Alternative terms: Furans; Tetrahydrofurans;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.383.312;