GABA Agonists - Pharmacology
Research News and Information

Saturday, November 21, 2009

Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons.

30 Oct 2009 Rundown is ubiquitously seen in response to repetitive activation of receptor or ion channels as a use-dependent down-regulation through various mechanisms. In contrast to AMPA receptors, gamma-aminobutyric acid type A receptor (GABA(A)R) are ... Read more...

Double dissociation and hierarchical organization of strategy switches and reversals in the rat PFC.

29 Sep 2009 Prelimbic-infralimbic cortex (PL-IL) and orbitofrontal cortex (OFC) influence behavioral flexibility in the rat. The authors tested the effects of PL-IL or OFC infusion with the GABA agonist muscimol in the context of 2 flexible responding tasks: ... Read more...

Inbred mouse strains differ in multiple hippocampal activity traits.

2 Sep 2009 A major challenge in neuroscience is to identify genes that influence specific behaviors and to understand the intermediary neuronal mechanisms. One approach is to identify so-called endophenotypes at different levels of neuronal organization from ... Read more...

Latest indexed articles for 'GABA Agonists - Pharmacology'

These are the very latest articles for this heading:

• Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons. 30 Oct 2009
• Double dissociation and hierarchical organization of strategy switches and reversals in the rat PFC. 29 Sep 2009
• Inbred mouse strains differ in multiple hippocampal activity traits. 2 Sep 2009
• Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction. 23 Aug 2009
• Hibernation induces pentobarbital insensitivity in medulla but not cortex. 10 Aug 2009
• The rat prelimbic cortex mediates inhibitory response control but not the consolidation of instrumental learning. 30 Jul 2009
• Behavioral characterization of amygdala involvement in mediating intra-accumbens opioid-driven feeding behavior. 30 Jul 2009
• Temporary inactivation of ventral tegmental area neurons with either muscimol or baclofen reversibly disrupts maternal behavior in rats through different underlying mechanisms. 30 Jul 2009
• Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice. 30 Jul 2009
• Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome. 30 Jul 2009
• Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling. 30 Jul 2009
• GABA(B) receptor activation inhibits neuronal excitability and spatial learning in the entorhinal cortex by activating TREK-2 K+ channels. 28 Jul 2009
• Clozapine, GABA(B), and the treatment of resistant schizophrenia. 20 Jul 2009
• Novel environment and GABA agonists alter event-related potentials in N-methyl-D-aspartate NR1 hypomorphic and wild-type mice. 12 Jul 2009
• Role for GABA agonists in the nucleus accumbens in regulating morphine self-administration. 8 Jul 2009
• Endogenous angiotensin II facilitates GABAergic neurotransmission afferent to the Na+-responsive neurons of the rat median preoptic nucleus. 6 Jul 2009
• GABAergic antagonism of the central nucleus of the amygdala attenuates reductions in rapid eye movement sleep after inescapable footshock stress. 29 Jun 2009
• Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway. 29 Jun 2009
• Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348). 27 Jun 2009
• Functional significance of nonspatial information in monkey lateral intraparietal area. 22 Jun 2009

See a longer list of these articles.

Technical information about 'GABA Agonists'

Definition: Drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA).

Registry Number: 0

Descriptor UI: D018755

Alternative terms: GABA Agonists; Agonists, GABA; gamma-Aminobutyric Acid Agonists; Acid Agonists, gamma-Aminobutyric; Agonists, gamma-Aminobutyric Acid; gamma Aminobutyric Acid Agonists; GABA Receptor Agonists; Agonists, GABA Receptor; Receptor Agonists, GABA; GABA Receptor Agonist; Agonist, GABA Receptor; Receptor Agonist, GABA; gamma-Aminobutyric Acid Agonist; Acid Agonist, gamma-Aminobutyric; Agonist, gamma-Aminobutyric Acid; gamma Aminobutyric Acid Agonist; GABA Agonist; Agonist, GABA;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.625.240.200; D27.505.696.577.240.200;

History Note: 95

Technical Notes: GEN or unspecified; prefer specifics; do not confuse with GABA ANTAGONISTS; DF: GABA AGON or GABA AG