GABA Antagonists - Pharmacology
Research News and Information

Sunday, November 22, 2009

The time course of dopamine transmission in the ventral tegmental area.

19 Oct 2009 Synaptic transmission mediated by G-protein coupled receptors (GPCR) is not generally thought to be point-to-point. To determine the extent over which dopamine signals in the midbrain, the present study examined the concentration and time course of ... Read more...

Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities.

19 Oct 2009 Homeostatic regulation of synaptic strength in response to persistent changes of neuronal activity plays an important role in maintaining the overall level of circuit activity within a normal range. Absence of miniature EPSCs (mEPSCs) for a few ... Read more...

Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity.

12 Oct 2009 Estrogen, in addition to its genomic effects in brain, causes rapid and reversible changes to synaptic operations. We report here that these acute actions are due to selective activation of an actin-signaling cascade normally used in the production ... Read more...

Latest indexed articles for 'GABA Antagonists - Pharmacology'

These are the very latest articles for this heading:

• The time course of dopamine transmission in the ventral tegmental area. 19 Oct 2009
• Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. 19 Oct 2009
• Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. 12 Oct 2009
• Role of GABA transporter 3 in GABAergic synaptic transmission at striatal output neurons. 29 Sep 2009
• Dynamics of fast and slow inhibition from cerebellar golgi cells allow flexible control of synaptic integration. 22 Sep 2009
• GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses. 14 Sep 2009
• The timing of external input controls the sign of plasticity at local synapses. 4 Sep 2009
• Calcium control of gene regulation in rat hippocampal neuronal cultures. 30 Aug 2009
• Long-term potentiation in the rat medial vestibular nuclei depends on locally synthesized 17beta-estradiol. 24 Aug 2009
• Linking genetically defined neurons to behavior through a broadly applicable silencing allele. 11 Aug 2009
• Hibernation induces pentobarbital insensitivity in medulla but not cortex. 10 Aug 2009
• Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure. 5 Aug 2009
• Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice. 30 Jul 2009
• Hippocampal synapsin isoform levels are linked to spatial memory enhancement by SGS742. 30 Jul 2009
• gamma-Aminobutyric acid-mediated regulation of the activity-dependent olfactory bulb dopaminergic phenotype. 30 Jul 2009
• Intensity of GABA-evoked responses is modified by nitric oxide-active compounds in the subthalamic nucleus of the rat: a microiontophoretic study. 30 Jul 2009
• Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling. 30 Jul 2009
• Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. 28 Jul 2009
• Blocking GABAA neurotransmission in the interposed nuclei: effects on conditioned and unconditioned eyeblinks. 23 Jul 2009
• Intracellular acidification causes adenosine release during states of hyperexcitability in the hippocampus. 20 Jul 2009

See a longer list of these articles.

Technical information about 'GABA Antagonists'

Definition: Drugs that bind to but do not activate GAMMA-AMINOBUTYRIC ACID receptors, thereby blocking the actions of endogenous GAMMA-AMINOBUTYRIC ACID or GAMMA-AMINOBUTYRIC ACID agonists.

Registry Number: 0

Descriptor UI: D018756

Alternative terms: GABA Antagonists; Antagonists, GABA; GABA Receptor Antagonists; Antagonists, GABA Receptor; Receptor Antagonists, GABA; gamma-Aminobutyric Acid Antagonists; Acid Antagonists, gamma-Aminobutyric; Antagonists, gamma-Aminobutyric Acid; gamma Aminobutyric Acid Antagonists; GABA Antagonist; Antagonist, GABA;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.625.240.300; D27.505.696.577.240.300;

History Note: 95

Technical Notes: GEN or unspecified; prefer specifics; do not confuse with GABA AGONISTS; DF: GABA ANTAG